The Lappalainen Lab (http://tllab.org) studies genetic variation in human populations affecting molecular, cellular, and high-level traits and diseases. We use both computational and experimental methods to study these questions, with an interdisciplinary integration of approaches from computational genetics, population genetics, functional genomics, and molecular genetics. Our particular focus is on integration of large-scale genome and transcriptome sequencing data sets. We are part of several large consortia, including GTEx and MoTrPAC.
Our laboratory is seeking a skilled and motivated molecular biologist to join our team. The experimental work of our research group focuses on genome editing of human cell lines by CRISPR/Cas9 technology to study functional variants in the human genome and analyze their impact on gene expression.
Responsibilities include, but are not limited to:
- Conduct, design, and troubleshoot experiments, independently and in collaboration with colleagues, to edit genomes in human cell lines and primary cells in support of project goals;
- Manage small independent projects that include optimization of experimental procedures;
- Analyze results of experiments together with other members of the team;
- Consult with scientific literature and other scientists as needed to better understand scientific experiments and problems, and come up with solutions to emerging problems;
- Operate and maintain multiple laboratory instruments;
- Assist in maintaining general laboratory functionality, including ordering and tracking lab supplies;
- Record and communicate findings accurately and professionally.