Associate Scientist I, Molecular & Cellular Biology

Organization
New York Genome Center
Job Location
101 Avenue of the Americas
New York, NY 10013
Job Description

The Lappalainen Lab (http://tllab.org) studies genetic variation in human populations affecting molecular, cellular, and high-level traits and diseases. We use both computational and experimental methods to study these questions, with an interdisciplinary integration of approaches from computational genetics, population genetics, functional genomics, and molecular genetics. Our particular focus is on integration of large-scale genome and transcriptome sequencing data sets. We are part of several large consortia, including GTEx and MoTrPAC.

Our laboratory is seeking a skilled and motivated molecular biologist to join our team. The experimental work of our research group focuses on genome editing of human cell lines by CRISPR/Cas9 technology to study functional variants in the human genome and analyze their impact on gene expression.

Responsibilities include, but are not limited to:

  • Conduct, design, and troubleshoot experiments, independently and in collaboration with colleagues, to edit genomes in human cell lines and primary cells in support of project goals;
  • Manage small independent projects that include optimization of experimental procedures;
  • Analyze results of experiments together with other members of the team;
  • Consult with scientific literature and other scientists as needed to better understand scientific experiments and problems, and come up with solutions to emerging problems;
  • Operate and maintain multiple laboratory instruments;
  • Assist in maintaining general laboratory functionality, including ordering and tracking lab supplies;
  • Record and communicate findings accurately and professionally.
Requirements
  • B.Sc. or M.Sc. in biology, biochemistry, biotechnology, or equivalent field.
  • Minimum of 1 year of academic laboratory or industry experience.
  • Exceptional research, time management, problem solving and communication skills (both written and oral) coupled with a strong attention to detail and scientific curiosity.
  • Excellent interpersonal skills and ability to work efficiently in a dynamic, multidisciplinary environment are essential.
  • The ideal candidate is proficient in at least one of the following disciplines:
    • Primary cell and tissue culture;
      • Standard cell culture support, including maintaining, freezing and plating of cell lines;
      • Delivery of DNA/RNA/protein by electroporation (including nucleofection) or lipofection;
    • Molecular genetics;
      • Ability to perform routine molecular biology techniques, such as isolation and quantification of DNA and RNA using standard kits, PCR, colony PCR, quantitative RT-PCR, sub-cloning and bacterial transformation;
    • Flow cytometry or other automated lab equipment;
      • Experience with flow cytometric analyses including viability and phenotypic characterization of cell populations;
    • Experience with robotics and high-throughput workflows;
      • Hands-on experience with CRISPR/Cas9 or other gene editing approaches is a plus;
      • High-throughput sequencing experience and basic data analysis skills are a plus.
How to Apply
About Our Organization

The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research. 

The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, or protected veteran status. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

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