Associate Scientist I / II - DMPK - Mass Spectrometry

Job Location
Mountain View, CA
Job Description

If you're inspired by the possibilities of science to change lives and you thrive when making brave decisions - join us.
MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you'll have the opportunity to make a difference in people's lives every day. As one of the world's premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  As an Associate Scientist I / II in Mountain View, CA,  you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives.
And we're excited to share that our work at the Mountain View site (along with some other AstraZeneca Group Companies in the Bay Area) will relocate to South San Francisco in early 2018.  Click here for more information on this new facility. 
We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we're industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.
MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.


Main Duties and Responsibilities 
We are seeking an Associate Scientist I or II , individual contributor to join DMPK department supporting clinical and pre-clinical PK/PD and non-clinical toxicology studies. Your primary responsibilities will include development, validation/qualification of quantitative mass spectrometry assays to support pharmacokinetic/toxicokinetic/pharmacodynamic analyses in variety biological matrices as well sample analysis. You will utilize mass spectrometry for detection and quantification of therapeutic peptides and antibodies, including ADCs, small molecules and various biomarkers (proteins, lipids, metabolites).  You will adhere to established Standard Operating Procedures and contribute to validation protocols, reports and bioanalytical reports. You will demonstrate competency in troubleshooting, optimization and implementation of challenging and innovative LC-MS/MS assays.
Essential Requirements 
For Associate Scientist I: 

•B.S. in Chemistry, Biochemistry or Pharmaceutical Sciences
•5-8 years of relevant experience 

•M.S. in Chemistry, Biochemistry or Pharmaceutical Sciences
•2-5 years of relevant experience 
For Associate Scientist II: 

•B.S. in Chemistry, Biochemistry or Pharmaceutical Sciences
•8-10 years of relevant experience 

•M.S. in Chemistry, Biochemistry or Pharmaceutical Sciences
•5-8 years of relevant experience 
For both roles: 

•Strong background in analytical biochemistry/chemistry with emphasis on mass spectrometric bioanalysis of biotherapeutics (peptides, antibodies, ADCs), small molecules, biomarkers (proteins, lipids, metabolites)
•Hands-on experience with chromatographic separation of various analytes by LC and characterization and quantification by MS or MS/MS
•Significant experience in method development and troubleshooting
•Proficiency with mass spectrometry software as well as spreadsheet, word processing, and graphical computer programs
•Good organizational, documentation and technical writing skills
•Good command of English (written and oral)
•Strong communication and interpersonal skills 
Desirable Requirements 

•Industry experience
•Knowledge of chromatographic assay validation guidelines and GLP regulations
•Small-molecule mass spectrometry experience
•Familiarity with basic pharmacokinetic data analyses
•Familiarity with metabolite identification and profiling studies 
Next Steps - Apply today! 
To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. 

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