You will research the causes of autism by analyzing the world’s largest collection of autism genetic data and be the hands-on leader of the bioinformatics group in the Seaver Autism Center. You and the bioinformatics group will be a key component of two large, on-going, international autism genetics research projects, the Autism Sequencing Consortium (ASC) and the Population-Based Autism Genetics and Environment Study (PAGES). The group also provides bioinformatic support for other activities in Seaver. Our papers above report ASC and PAGES findings.
Qualified candidates must be able to work collaboratively with a diverse team that includes senior research scientists, computational geneticists, molecular biologists, and support staff such as High Performance Computing (HPC) engineers.
Your main responsibilities include:
- Analyze and share data in collaboration with colleagues in the ASC and PAGES projects.
- Lead a research initiative within the ASC.
- In close collaboration with the director of the Seaver Autism Center, Prof. Joseph Buxbaum, plan and guide the strategy for software development and data management in the Seaver bioinformatics group.
- Co-supervise other member(s) of the bioinformatics group with Prof. Buxbaum.
While conducting research, you will preform the following types of activities:
- Design, develop and run computational and statistical methods to advance our understanding of the role of DNA variants in autism. Use, evaluate and tune existing methods.
- Maintain expertise in published autism genetics research.
- Propose and develop new computational approaches for researching the genetics of autism. Clearly define the hypotheses to be tested by your proposed approaches and methodologies for evaluating their results.
- Prepare results for presentations, publications, and grant applications.
- Communicate research results to the scientific community via published papers.
While supporting the research of our collaborators, you will:
- Acquire and/or develop database software for managing the autism genetics data stored by the ASC and PAGES at Mount Sinai. Supervise the deployment and ongoing use of this software.
- Organize and backup large genetic datasets, and share them with members of the Seaver Center and external collaborators.
- Design, develop and run software pipelines for handling and analyzing large genetic datasets.
- Manage the group’s use of disk and other system resources on Sinai’s Linux cluster.