Assay Development Scientist / Engineer

Circulomics Inc
Job Location
Baltimore, MD
Job Description

We're looking for smart, dedicated and creative people to join our team. As in any startup environment, candidates who are flexible enough to fill many roles can be expected to grow quickly within the company and play a large part in shaping its future. Today, you may be working at the lab bench while tomorrow, you may be writing a patent, and the day after, you may be meeting with customers.

Applicant's primary responsibility is the development, validation, and benchmarking of the Ligo-miR multiplex microRNA assay platform. The candidate will be responsible for expanding the Ligo-miR technology portfolio to perform microRNA profiling in cells and tissues, biofluids, and single cells. This position could also include potential involvement with the development of our nanotechnology based DNA and RNA extraction methods. The ideal candidate would also welcome broad exposure to all aspects of bringing a novel technology to market.

Specific responsibilities include:
• Optimization of assay design and reaction conditions
• Optimization of probe design and development of probe design algorithms
• Development of data analysis methods and algorithms
• Development of fluorescent detection methods using polyacrylamide gel electrophoresis
• Development of fluorescent detection methods using high throughput capillary electrophoresis
• Development of fluorescent detection methods using our PicoSep microfluidic, single molecule DNA sizing platform
• Benchmarking against established technologies such as RT-qPCR and microarray
• Clinical sample analysis and biomarker development
• Deployment of assay technologies at academic collaborator and customer sites


B.S., M.S., or PhD in Engineering fields, Biological sciences, or Chemical sciences.

Desired skills:
• Significant experience in molecular assay techniques including PCR, DNA ligation, nucleic acid isolation, nucleic acid probe design, and assay optimization.
• Strong understanding of the thermodynamics and biophysics of nucleic acid hybridization, probe design, enzyme kinetics, and chemical reactions
• Strong quantitative analysis, troubleshooting, and statistical analysis skills
• The ability to program in Matlab or equivalent languages for data analysis, image analysis, and bioinformatics analysis
• Experience with multiplexed assays, biomarker development, clinical diagnostics, capillary electrophoresis, single molecule analysis, and microRNA are a plus
• Demonstrated experience in conceptualizing, leading, and performing independent research
• Additional experience in business development and guiding a product to the marketplace would also be considered.
• Anything else to help the company grow and expand!

About Our Organization

Circulomics Inc is a Baltimore, MD biotechnology startup developing micro-, nano-, and single molecule technologies for biomarker analysis and clinical diagnostics. These technologies encompass the entire molecular analysis workflow from front-end sample preparation to assays and detection instruments. Circulomics' core Ligo-miR technology enables capture of an entire microRNA expression signature in a single streamlined assay. By eschewing conventional array and PCR based approaches, Ligo-miR achieves state-of-the-art sensitivity, greatly enhanced sample throughput, and significantly reduced assay costs without requiring costly, proprietary instrumentation. By focusing on the need for high performance assay solutions with exceptionally low barriers to adoption, Circulomics and Ligo-miR technology will lead the microRNA market through the rapid clinical translation of these promising biomarkers.

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