Applications Staff Scientist (Lab Lead)

10x Genomics
Job Location
San Francisco Bay Area, CA
Job Description

10x Genomics is looking for an outstanding scientist to join its Applications Development group. The scientist must have a passion for innovating new applications that use Next Generation Sequencing technologies to drive discovery and improve human health. The scientist must have excellent laboratory skills, be able to learn quickly, and creatively solve problems. The ideal candidate will have a PhD and at least 5 years of experience in biochemistry, molecular biology, or genetics, and have experience applying NGS technology to explore challenging biological questions. You will lead a team of scientists in applying 10x technology to explore a wide variety of applications. Candidates with experience in core facilities are strongly encouraged to apply.   

Key Responsibilities

  • Lead a team of scientists to expand the applications using 10x technology
  • Plan, execute and troubleshoot experiments using 10x technology
  • Work with early access customers to test new products and applications
  • Develop and run internal product validation efforts
  • Use 10x Genomics’ platform to develop novel NGS applications
  • Produce proof-of-concept data sets to demonstrate the unique power of the 10x Genomics platform internally and externally
  • Write applications notes and protocols for users of the 10x Genomics platform
  • Required Skills and Background
  • PhD or equivalent in biochemistry, molecular biology, genetics, or a related field
  • Deep understanding of the NGS applications space, particularly as related to human health (e.g., sequencing applied to RNA, cancer, single cells)
  • Experience with existing NGS platforms (e.g., Illumina, Ion Torrent, PacBio, etc.)
  • Demonstrated ability to trouble-shoot complex problems and to work effectively in a multi-disciplinary team
  • An eagerness to dramatically improve NGS tools
  • Strong organizational skills
  • Strong written and oral communication skills demonstrated with peer-reviewed publications and conference presentations
  • Demonstrated ability to maintain relationships with customers or external collaborators


  • Desired Skills and Background
  • Experience analyzing large sequencing data sets
  • Understanding of statistical methods used in RNA sequencing experiments
  • Experience with NGS-related products such as Agilent SureSelect target capture, Ion AmpliSeq, Fluidigm single cell sequencing, etc.
  • Experience with DNA and/or RNA extraction methods
  • Deep knowledge of RNA or cellular biology in cancer or immunology contexts
  • Experience with other laboratory assays including real-time PCR, droplet digital PCR
  • Understanding of gene editing methods including CRISPR
About Our Organization

10x Genomics meets the critical need for long range, structural and cellular information, with an innovative system that transforms short-read sequencing technologies. Our ChromiumTM System supports comprehensive genomics and high-throughput single cell transcriptomics. It enables researchers to discover previously inaccessible genomic information at unprecedented scale, including phased structural variants, phased single nucleotide variants, and dynamic gene expression of individual cells—while leveraging their existing sequencing systems and workflows.

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