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Post Doc Computational - Siepel Lab


Cold Spring Harbor Laboratory

Job Location

1 Bungtown Road
Cold Spring Harbor, NY 11724
United States

Job Description

Position Description

A postdoctoral position in COMPUTATIONAL GENOMICS is available in Dr. Adam Siepel’s research group at the Simons Center for Quantitative Biology (SCQB), Cold Spring Harbor Laboratory.

The Siepel Group specializes in the development of probabilistic models and algorithms for inference, machine-learning methods, and applications in large-scale genomic data analysis. Of particular interest is research relevant to existing NIH-supported projects in:

1. EVOLUTIONARY GENOMICS of humans and other mammals, including inference of ancestral recombination graphs, detection of selective sweeps, comparative genomics of bats, inference of distributions of fitness effects and quantification of genetic load from linked deleterious alleles; and

2. TRANSCRIPTIONAL REGULATION in mammals, including quantification of initiation and pause-release rates from nascent RNA sequencing data, characterization of elongation rates, and evolutionary analysis of transcriptional regulation across primates and other mammals.


1. Danko CG, Choate LA, Marks BA, Rice EJ, Zhong W, …, & Siepel A. Dynamic evolution of regulatory element ensembles in primate CD4+ T-cells. Nat Ecol Evol 2:537-548 (2018).
2. Huang, Y.-F. & Siepel, A. Estimation of allele-specific fitness effects across human protein-coding sequences and implications for disease. Genome Res 29, 1310–1321 (2019).
3. Hejase, H. A. et al. Genomic islands of differentiation in a rapid avian radiation have been driven by recent selective sweeps. PNAS 7, 202015987 (2020).
4. Hubisz, M. J., Williams, A. L. & Siepel, A. Mapping gene flow between ancient hominins through demography-aware inference of the ancestral recombination graph. PLOS Genetics 16, e1008895 (2020).
5. Dukler, N., Huang, Y.-F. & Siepel, A. Phylogenetic modeling of regulatory element turnover based on epigenomic data. Mol Biol Evol 37:2137-2152 (2020).
6. Blumberg, A. et al. Characterizing RNA stability genome-wide through combined analysis of PRO-seq and RNA-seq data. BMC biology 19, 1–17 (2021).
7. Hutton, E. R., Vakoc, C. R. & Siepel, A. ACE: a probabilistic model for characterizing gene-level essentiality in CRISPR screens. Genome Biol 22, 278 (2021).
8. Hejase, H. H., Mo, Z., Campagna, L. & Siepel, A. A deep-learning approach for inference of selective sweeps from the ancestral recombination graph. Mol Biol Evol 7:msab332 (2022).
9. Dukler, N., Mughal, M. R., Ramani, R., Huang, Y.-F. & Siepel, A. Extreme purifying selection against point mutations in the human genome. Nature Communications, in press.


Position Requirements
Candidates should hold a Ph.D. in bioinformatics, computer science, statistics, genetics, molecular biology, applied mathematics, or a related field. Research experience (with first-author publications) in computational genomics or a closely related field.
Experience with probabilistic modeling, computational statistics, and/or machine-learning. Proficiency in programming, ideally in python, R, or C/C++. Should be comfortable in a Linux environment, with large data sets and computer clusters.

Supplemental Information

Compensation and Benefits
Our employees are compensated in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, paid time off, and a range of recognition and wellness programs. Visit our CSHL Benefits , Postdoctoral Landing & Postdoctoral Fellow Stipend Schedule (Download PDF reader) (Download PDF reader) (Download PDF reader) sites to learn more.

You are required to be fully vaccinated for COVID-19 as a condition to your employment at the Laboratory. You will be required to provide proof of your vaccination on your first day of employment. For those individuals, who are unable to receive a vaccine due to access issues, they will be expected to receive the vaccine upon arrival in New York.

CSHL is an EO/AA Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, or protected veteran status. VEVERRA

How to Apply

Interested candidates should submit a CV, a short description of research interests and experience, and contact information for three references, by email to [email protected]. Informal inquiries are also welcome. In addition, candidates should apply online at: Position ID: 02744-R

About Our Organization

Cold Spring Harbor Laboratory is a world-renowned biomedical research institution in New York. It has shaped contemporary biomedical research and is the home of eight Nobel Prize laureates. Cold Spring Harbor Laboratory provides a highly dynamic and interactive research environment and also a unique opportunity of timely exposure to advances in various biomedical research fields and of interaction with a broad range of researchers from all over the world through its renowned Meetings and Courses program.

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