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Staff Associate II - Sims Lab


Columbia University Irving Medical Center

Job Location

630 West 168th Street
New York, NY 10032
United States


$80,000 - $90,000


Columbia University offers generous and flexible health and welfare plans for you and your family; and generous paid time off benefits and robust wellness programs.

Job Description

The Sims Lab in the Department of Systems Biology at Columbia University Irving Medical Center is seeking a Staff Associate II to provide computational biology and bioinformatics support to a large-scale immunological profiling project involving perturbation of live human tissues, single-cell genomics, and several other molecular profiling technologies. The effort will involve the development and application of platform technologies for analyzing vaccine responses as part of a team of investigators and researchers at Columbia. The Sims Lab has similar technology development efforts in cancer biology, and there will be opportunities to become involved in these projects as well.

Duties and Responsibilities:

-Key responsibilities include the maintenance and implementation of computing pipelines for analyzing CITE-seq, single-cell RNA-seq, single-cell DNA-seq, single-cell ATAC-seq, and immune repertoire profiling data.
-Research duties include managing data storage, data transfer, data sharing, data processing (i.e. demultiplexing and alignment of sequencing data), and downstream data analysis (i.e. unsupervised clustering, differential expression analysis, data visualization, data integration, statistical inference, classification).
-Computational analysis will take advantage of a cloud computing infrastructure.
-Related responsibilities include keeping detailed written and computer records of computational methods and presenting results to the principal investigator and other team members.


Minimum Qualifications:

-Bachelor’s degree in biology, chemistry, physics, math, engineering, bioinformatics, computer science or a related field.
-Experience with bioinformatic analysis of genomic and/or transcriptomic sequencing data.
-Experience working with a Linux operating system.
-Experience working with and fluency in at least one high-level programming language (e.g. Python, R, or similar).
-Excellent communication skills and teamwork.
-Strong creative thinking and problem-solving skills.

Preferred Qualifications:

-Graduate degree in biology, chemistry, physics, math, engineering, bioinformatics, computer science or a related field.
-Working knowledge of immunology.
-Experience analyzing single-cell genomic data (e.g. scRNA-seq, scATAC-seq, CITE-seq, single-cell immune repertoire sequencing, scDNA-seq).
-Experience with cloud computing (e.g. Amazon Web Services).

How to Apply

To be considered for this position, you need to apply directly on Columbia's academic careers website by going to the following link:

About Our Organization

Columbia University Irving Medical Center (CUIMC) is a clinical, research, and educational enterprise located on a campus in northern Manhattan. We are home to four professional colleges and schools that provide global leadership in scientific research, health and medical education, and patient care.

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