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Scientist (Protein Chromatography)

Organization

Invenra

Job Location

505 South Rosa Road
Madison, WI 53719
United States

Benefits

Benefits:

Includes a competitive compensation and benefits package composed of health and dental benefits, 401k match, stock option grants, PTO, tuition reimbursement, a generous bonus plan and relocation assistance. At Invenra, we believe in maintaining the highest ethical standards and ensuring that all employees have a good work-life balance.

Invenra is committed to a diverse workforce. We believe every individual brings their own unique experience, and these experiences foster innovation and success. We are enthusiastically inclusive of age, race, creed, color, disability, marital status, sex, national origin, ancestry, sexual orientation, and military service.

Job Description

Position Summary:

Invenra is seeking an experienced, instrumentation-savvy analytical Scientist to join our Protein Characterization/Analytics team. For this position, we are seeking a candidate with strong technical competencies regarding operation and repair of chromatographic instrumentation and expert grasp of the fundamentals of chromatographic separations including underlying chemistry. This individual will assume responsibility for protein chromatography quality control, assay development, and instrumentation troubleshooting (including maintenance/repair) to support Invenra’s numerous pre-clinical protein biotherapeutic programs. This position reports to the Director of the Analytics group.

Key Responsibilities:

  • Perform QA/QC characterization of antibodies, antigens, and other engineered proteins by HPLC using SEC, HIC, IEX, and SMAC techniques with UV, fluorescence, and/or MALS detection. Must endure data quality meets or exceeds quality criteria.
  • Perform affinity purification and/or 2nd-step polishing of proteins by gravity filtration, HPLC, and/or FPLC.
  • Ensure HPLC and FPLC instrumentation are within operational specifications.
  • Employ new strategies for protein characterization using chromatographic techniques.
  • Develop and/or modify purification techniques to improve protein yield, protein purity, and sample throughput.
  • Establish suitable standards and controls for new assays and writing standard operating procedures for use.
  • Prepare analytical standards, chromatographic mobile phases, and reagent stocks.
  • Analyze and interpret data from multiple assays prior to compiling and communicating results.
  • Serve as a representative of Analytics Team on project core teams.

Requirements

Required Education, Experience, and Competencies:

  • Bachelor’s, Master’s or Ph.D. in chemistry, biochemistry, or other biological/physical science discipline with 0-2 years (Ph.D.), 3+ years, (M.S.) and 5+ years (B.S.) of relevant industry experience.
  • Mastery of chromatographic separations and operation of analytical instrumentation is required.
  • Must be capable of routine maintenance of HPLC/FPLC instrumentation including replacing pump seals/pistons, injection valve repair, and replacement of sampling needles and in-line filters.
  • The ideal candidate should be capable of advanced HPLC/FPLC instrument troubleshooting and repair including diagnosing faulty electronic boards and performing major hardware repairs (replacing pump assemblies, replacing transport carriages, rebuilding detection cells and degassers, etc.).
  • Must have solid grasp of underlying chemistry governing chromatographic separations including the variables that can be adjusted to achieve the desired experimental outcome.
  • The ability to execute routine work at expected quality with minimal supervisory oversight is a requirement.
  • Must be willing to mentor junior scientists, research associates, and interns while fostering a laboratory environment comprising analytical rigor, creativity, and accountability.
  • Must adhere to standard operating procedures, when required.
  • Must be reliable, have a professional attitude, and maintain positive group dynamic through effective and timely communication.
  • Should embrace working in a fast-paced environment, with multiple projects and evolving priorities.

Preferred, but not required:

  • Experience with protein chromatography strongly preferred.
  • Experience analyzing/purifying biomolecules including mono-/multi-specific antibodies, nanobodies (VHH), cell-surface proteins, and affinity-tagged proteins is highly desired.
  • Experience using and interpreting data from multiangle light scattering instrumentation (MALS) is a plus.

Note: All job candidates must be authorized to work in the United States.

About Our Organization

About Invenra:

We are a rapidly expanding and well-funded biotechnology company focused on employing cutting edge protein engineering and multi-specific antibodies to discover therapeutic solutions to challenging diseases. At Invenra, we start with biology, then employ our extensive technology toolbox and efficient discovery engine to design and create first- and best-in-class drug candidates. Using our proprietary B-BODY™, SNIPER™ and CLUSTR™ technologies, we have generated a robust pipeline of next-generation multi-specific antibodies to address unmet therapeutic needs in immuno-oncology and autoimmunity. Invenra’s employee-focused management and flexible work environment creates a culture of energy and innovation where everyone makes a difference, and everyone benefits from success. For more information, please visit www.invenra.com.

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