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Research Technician - Kingsley Lab

Organization

Howard Hughes Medical Institute (HHMI)

Job Location

Beckman Center
Stanford, CA 94305
United States

Salary

Competitive

Benefits

Full Benefits Package

Job Description

We are currently looking for an enthusiastic, detail-oriented Research Technician to join the laboratory of Dr. David Kingsley at Stanford University.

The Kingsley lab uses a combination of genetic and genomic approaches to identify the detailed molecular mechanisms that control evolutionary change in vertebrates.   By crossing and sequencing recently diverged populations and species, the lab is revealing answers to several long-standing biological questions:  

1. Are key evolutionary traits controlled by countless genetic differences of small effect, or by a few genetic changes with large effects?
2. What specific genes have changed to produce interesting evolutionary differences seen in nature?
3. What kinds of mutations have occurred in these genes (e.g., dominant or recessive, coding or regulatory, preexisting or de novo)?
4. How predictable is evolution? If you know how evolution has occurred in one population, is it possible to predict the types of genes and mutations that also underlie the same trait in different populations or species?
5. How has evolution produced the unique characteristics, and the common traits and diseases, found in humans?

The lab studies these questions using a variety of genetic and genomic methods in mice, stickleback fish, and human beings. More information about the Kingsley lab can be found here: https://kingsley.stanford.edu/

The Research Technician will contribute to the Kingsley lab’s goals by assisting with collection of unique fish populations from the wild, breeding of different populations in an aquatic fish facility at Stanford, preparing and analyzing DNA and RNA samples, scoring phenotypic traits, and generating modified fish lines to test the phenotypic consequences of particular DNA changes.

Essential Duties and Responsibilities

  • Assisting with collection of unique fish populations from wild

  • Breeding of different fish populations in an aquatic facility at Stanford

  • Preparing and analyzing DNA and RNA samples

  • Scoring morphological traits in genetic crosses

  • Generating modified fish lines to test the phenotypic consequences of particular DNA changes

  • Contributing to co-authored manuscripts describing research results and advances

Requirements

Education
A bachelor’s degree in molecular biology, evolutionary biology, genetics, or genomics (or a closely related discipline) or an equivalent combination of education and experience is required.

Experience

Previous experience with basic molecular biology methods (DNA and RNA isolation, PCR, DNA cloning and sequencing, etc.) in an academic laboratory setting is required.

Previous experience with breeding and managing genetic pedigrees of vertebrate or invertebrate animals is preferred.

Previous experience with embryo microinjection or manipulation would be a plus.

Knowledge, Skills, and Abilities

Strong interpersonal skills and ability to work well with lab members at all career levels.

Strong verbal and written communication skills.

Strong attention to detail and high degree of accuracy in research and writing.

Strong problem-solving skills with ability to think creatively.

Strong desire to learn new techniques, grow professionally, and be mentored by more senior scientists.

 

HHMI is an Equal Opportunity Employer

About Our Organization

Howard Hughes Medical Institute (HHMI) is an independent, ever-evolving philanthropy that supports basic biomedical scientists and educators with the potential for transformative impact. We make long-term investments in people, not just projects, because we believe in the power of individuals to make breakthroughs over time.

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