Skip to main content
Premium Trial:

Request an Annual Quote

NSF Awards $2.6M to Fund Research on Plant Long Non-Coding RNAs

NEW YORK (GenomeWeb) – The National Science Foundation recently awarded roughly $2.6 million to researchers from the University of Pennsylvania and the University of Arizona to investigate the role of long, non-coding RNAs in both the normal development and stress responses of various plant species.

"While the field of genetics has focused in large part on the functions of genes, investigations into the biology of lncRNA molecules are just now gaining steam," UA's Mark Beilstein said in a statement. "Uncovering the functions of lncRNA molecules is an important next step in elucidating how information flows from genomic DNA to RNA and proteins responsible for carrying out the work of the cell."

With the NSF funding, the scientists aim to identify and functionally characterize highly structured nuclear lncRNAs that are stress-responsive, protein-bound, and evolutionarily conserved in the model plants Eutrema salsugineum and Arabidopsis thaliana, as well as in crop species including Camelina sativa, Brassica rapa, Zea mays, and Sorghum bicolor.

Data generated through the work will be used to expand EPIC-CoGe, a central repository for plant epigenomics data maintained by the Epigenomics of Plants International Consortium.

"It is anticipated that … the project will provide novel insights into plant gene expression regulation by lncRNAs and provide important new findings and resources for studies focused on the improvement of numerous crop and genetic model plants," according to the grant's abstract.

The Scan

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.

Clinical Genomic Lab Survey Looks at Workforce Needs

Investigators use a survey approach in Genetics in Medicine Open to assess technologist applications, retention, and workforce gaps at molecular genetics and clinical cytogenetics labs in the US.

Study Considers Gene Regulatory Features Available by Sequence-Based Modeling

Investigators in Genome Biology set sequence-based models against observational and perturbation assay data, finding distal enhancer models lag behind promoter predictions.

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.