NEW YORK (GenomeWeb) - The National Institutes of Health plans to fund a coordination center to facilitate the replication phase of the Alzheimer's Disease Sequencing Project.
Supported by the National Institute on Aging, the funds will go toward establishing the NIA Coordinating Center for the Genetics and Genomics of Alzheimer's Disease.
The ultimate aim of the ADSP is to identify the genomic contributions to both risks for Alzheimer's and protection against the disease, as well as the correlation between human genetic variation and the relationship to health and disease. The discovery phase generated several data sets from whole-genome and whole-exome sequencing studies. The replication phase will examine a subset of genes, regions, and loci implicated during the discovery phase.
During the replication phase, findings of the discovery phase and other research groups will be confirmed and data will be aggregated, harmonized, and analyzed to identify and validate risk and protective alleles for Alzheimer's. Activities the center could facilitate and support include genome-wide association studies, genotyping by custom chip, targeted sequencing, data tracking, quality control checks, and other analyses.
To fund the center, NIA plans to commit $2.25 million in Fiscal Year 2016 comprising one new grant, with up to $2 million per year in direct costs for the duration of the project up to five years.
Applications will be accepted from May 3, 2015 until June 3, 2015.