Skip to main content
Premium Trial:

Request an Annual Quote

InSilixa Wins Funding to Develop POC MDx for HPV

NEW YORK (GenomeWeb) – Sunnyvale, California-based InSilixa has received funding to develop a point-of-care rapid molecular diagnostic assay for oral human papillomavirus detection, the company announced today.

The $224,764 Phase I Small Business Innovation Research grant was awarded by the National Institutes of Health.

The assay is "a potential new tool to screen oral specimens such as saliva for cancer-causing HPV types and to risk stratify those persons found to be positive,” Gary Schoolnik, chief medical officer of InSilixa, said in a statement.

The diagnostic will be based on InSilixa's proprietary complementary metal-oxide semiconductor, or CMOS, biochip. The chip enables rapid detection and genotyping of pathogens in clinical samples, as well as simultaneous drug-resistance profiling, using highly-multiplexed targeted DNA sequencing, according to the firm.

"The unique cost and performance of InSilixa’s CMOS biochips make it possible to create viable products in markets that historically have not been addressable by DNA sequencing technologies," Arjang Hassibi, InSilixa's CEO, noted. 

The firm completed a $13 million private financing round last year, and won $1.5 million in Phase II SBIR funding in April for a drug-resistant tuberculosis assay.

The HPV assay will also be based on a qPCR method developed by co-investigators at the University of North Carolina, according to the grant abstract.

That method is a multiplex assay that can detect, identify, and quantify HPV 6, 11, 16 and 18 L1 gene type-specific sequences, as well as HPV E1 gene consensus sequences common to all HPV types.

The firm said its first generation of products are focused on near-patient and point-of-care infectious disease molecular diagnostics. In addition to the HPV and TB assays, this includes rapid detection of multi-drug resistant bacteria in intensive care units, analysis of seasonal respiratory infection outbreaks, and quantification and genotyping of HIV in blood samples. 

The Scan

Not Yet a Permanent One

NPR says the lack of a permanent Food and Drug Administration commissioner has "flummoxed" public health officials.

Unfair Targeting

Technology Review writes that a new report says the US has been unfairly targeting Chinese and Chinese-American individuals in economic espionage cases.

Limited Rapid Testing

The New York Times wonders why rapid tests for COVID-19 are not widely available in the US.

Genome Research Papers on IPAFinder, Structural Variant Expression Effects, Single-Cell RNA-Seq Markers

In Genome Research this week: IPAFinder method to detect intronic polyadenylation, influence of structural variants on gene expression, and more.