NEW YORK (GenomeWeb) – Cofactor Genomics has recently received a $1.5 million Phase II SBIR grant from the National Institutes of Health to further develop a circular RNA enrichment technology.

Circular RNA is noncoding, present in the cytoplasm, plays a role in neuronal development, and can serve as a biomarker for psychiatric disorders, according to Cofactor. In addition, circRNAs are present in lower abundance than other RNA molecules, and share sequence homology with mRNA, so they are difficult to isolate from total RNA.

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