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CHORI Researcher Awarded $13.2M Grant to Study the Genomics of Statin Response

NEW YORK (GenomeWeb) – Children's Hospital Oakland Research Institute (CHORI) announced today that one of its researchers has received a $13.2 million grant from the National Institute of General Medical Sciences to identify the genetic mechanisms that influence patient response to statin drugs.

To oversee the project, CHORI's Ronald Krauss and collaborators have established a Center for Pharmacogenomics in Precision Medicine, applying genomic, transcriptomic, and metabolomic tools to studies in cellular and animal models of cardiovascular disease, CHORI said.

Also participating in the effort are investigators from the University of California, San Francisco; the University of California, Berkeley; the University of Washington; and Penn State.

Through the work, Krauss aims to identify new biomarkers that modulate the multiple actions of statins and that can be used to guide more effective use of this class of drugs, CHORI said.

"Our previous research has shown that investigation of molecular and cellular mechanisms influenced by statins can lead to identification of genetic variants that contribute to clinically important differences in response to statin treatment," Krauss said in a statement. "This grant allows us to extend this approach to identify genetic variants and molecular mechanisms that influence statin-related myopathy and new-onset diabetes."