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UCSD Lands $5.9M for Diabetes Systems Biology Study

NEW YORK (GenomeWeb News) – The University of California, San Diego has received a $5.9 million grant from the National Institutes of Diabetes and Digestive and Kidney Diseases to study epigenetic and metabolomic influences in type 1 and type 2 diabetes.

The researchers at the UCSD School of Medicine, led by principal investigator and Director of the Center for Renal Translational Medicine Kumar Sharma, will evaluate the urine metabolome of patients with diabetes and will try to determine if epigenetic modifications of certain genes can alter mitochondrial function in patients and animal models.

The UCSD team will use data from two large cohorts of patients from the Chronic Renal Insufficiency Cohort and the Finnish Diabetic Nephropathy Study, and will collaborate with the University of Pennsylvania.

"Using systems biology and imaging approaches, we hope to link measurement of mitochondrial function to metabolic alterations in the kidney – an approach that challenges prevailing theories about hyperglycemia-induced kidney disease," Sharma explained.

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