Skip to main content
Premium Trial:

Request an Annual Quote

Feinstein Institutes for Medical Research Wins $2.9M NIH Grant to Study Polygenic Embryo Screening

NEW YORK — The Feinstein Institutes for Medical Research on Monday said that it has received a $2.9 million grant from the National Institutes of Health to research the effects and implications of polygenic embryo screening.

While preimplantation genetic screening is widely used to avoid the implantation of embryos with rare monogenic disease-causing alleles or aneuploidies, PES uses polygenic risk scores to determine complex phenotypes, and the accuracy of such scores in the context of embryo screening is not well understood.

With the four-year grant, Feinstein researchers and collaborators from the Hebrew University of Jerusalem and Baylor College of Medicine will use a combination of simulated and real-world data to determine the ability of PES to reduce the risk of disease under varying conditions. The investigators will use in-depth interviews and a large-scale survey with reproductive clinicians and geneticists to understand the perspectives of those who administer PES.

"The use of polygenic embryo selection has been proposed as one tool to reduce the burden of disease in future generations," Todd Lencz, a Feinstein Institutes researcher and principal investigator of the grant, said in a statement. "With support from the NIH, we will be able to explore the ethical and scientific concerns and better understand the limitations PES may have."

The Scan

Harvard Team Report One-Time Base Editing Treatment for Motor Neuron Disease in Mice

A base-editing approach restored SMN levels and improved motor function in a mouse model of spinal muscular atrophy, a new Science paper reports.

International Team Examines History of North American Horses

Genetic and other analyses presented in Science find that horses spread to the northern Rockies and Great Plains by the first half of the 17th century.

New Study Examines Genetic Dominance Within UK Biobank

Researchers analyze instances of genetic dominance within UK Biobank data, as they report in Science.

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.