Waters has developed a new label-free, mass spectrometer-based method for absolute quantification of proteins.

The new method, published in the Oct. 11 issue of Molecular & Cellular Proteomics, relies on an "unexpected" relationship between protein concentration and the average MS signal response for the three most intense tryptic peptides, according to Jeff Silva, the first author of the study who is a senior research and development scientist in Waters' Core Technologies/Proteomics department.