Skip to main content
Premium Trial:

Request an Annual Quote

Vermillion Releases Initial Results from Vasclir Intended Use Study

Premium

This story originally ran on Oct. 6

Vermillion this week released top-line data from the intended use study for its peripheral artery disease biomarker test Vasclir.

The results demonstrated that the individual protein markers beta 2 microglobulin, cystatin C, and hsCRP are each expressed at statistically significant levels between PAD subjects and non-PAD subjects, the company said.

The biomarkers also showed correlation with the ankle-brachial index, a measure of the ratio of blood pressure in the lower legs to blood pressure in the arms that is used to detect PAD.

The intended use study was a prospective, doubled-blinded multicenter study of roughly 1,000 subjects at increased risk of PAD, including smokers and diabetics age 50 or above and elderly subjects 70 or above. It was done in conjunction with clinical research organization CPC Clinical Research.

Vasclir is the second test Quest Diagnostics accepted from the company as part of the partners' three-test strategic alliance agreement, and is currently one of Vermillion's primary research focuses.

In a statement, Vermillion CEO Gail Page said that the company's next steps for the test include "optimizing the panel composition as well as additional analyses comparing the panel with the American Heart Association cardiovascular risk score." The company plans to present final results from the study at a future cardiovascular meeting, she added.

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.