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A vast reserve of proteins exists within tissues that have been fixed in formalin and embedded in paraffin, but these proteins have been too difficult to extract for most large-scale proteomics experiments. Two new technologies have recently been developed, however, that could change the way proteomics researchers look at preserved tissues. The methods, from the University of Utah School of Medicine and the company Expression Pathology, enable proteins to be extracted and solubulized in a large-scale manner, and then identified by mass spectrometry.

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