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Thomson Reuters, AnaSpec, Agilent, LI-COR Biosciences

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Thomson Reuters this week launched the BIOMARKERcenter database which allows drug companies to assess the potential of a biomarker and to be alerted to changes in their status.
 
BIOMARKERcenter covers biomarkers described in literature, patents, conferences, clinical trials, and other sources for all major therapeutic areas, including oncology, cardiovascular disease, diabetes, and autoimmune disease.
 
The database contains biomarkers with established clinical usages as well as emerging uses for each biomarker. Data on the biomarkers include the name, classification, biological entities/processes involved, associated drugs, regulatory status, and related diagnostic kits.
 
BIOMARKERcenter is available as a stand-alone Web solution, a fully integrated component of Prous Science’s Integrity platform, or as an XML feed to internal customer databases.
 

 
AnaSpec this week said that it is offering custom synthesis of hydrocarbon-stapled peptides.
 
According to a statement from the company, intracellular protein-protein interactions are often mediated by alpha-helix structures of proteins. The use of short protein fragments leads to the loss of such secondary structures, but research has show that such problems can be overcome by a chemical modification of the alpha-helical peptide, called a hydrocarbon-stapled peptide. This modified peptide is “helical, relatively protease resistant, cell-permeable, and binds with increased binding affinity to its target,” AnaSpec said.
 
Hydrocarbon stapling may be a useful strategy in researching experimental and therapeutic modulation of protein-protein interactions and in vivo pharmacokinetic studies.
 
Also this week, the company introduced a new series of immunohistochemistry-validated antibodies, Anti-CARMA/CARD/Bimp antibodies. Immunohistochemistry of the antibodies was done by an anatomic pathologist on formalin-fixed, paraffin-embedded human or mouse tissues.
 

 
Agilent Technologies this week introduced the 3.3 revision of the EZChrom Elite chromatography data system.
 
The software is now localized into Chinese and Japanese, features a single walk-up sample entry screen, and offers updated workstation compliance. The revision has updated drivers for Agilent’s 1200 LC and the 7890 GC.
 

 
LI-COR Biosciences this week introduced the MPX Blotting System for its Quantitative Western Blotting product line.
 
The MPX can be incorporated into a variety of assays including primary and secondary antibody screening, monoclonal antibody screening, signal transduction pathway analysis, and other procedures requiring a PVDF or nitrocellulose blot of 7-by-8.5 cm, the company said in a statement.

The Scan

Rise of BA.5

The New York Times reports that the Omicron subvariant BA.5 has become the dominant version of SARS-CoV-2 in the US.

UK Health Secretary Resigns

Sajid Javid, the UK health secretary, resigned along with Chancellor Rishi Sunak, saying they cannot work with Prime Minister Boris Johnson's government, CNN reports.

Clones From Freeze-Dried Cells

A team in Japan has cloned mice from freeze-dried skin cells, according to the Guardian.

Genome Research Papers on Craniosynostosis, Macaque Retrotransposition, More

In Genome Research this week: structural variants in craniosynostosis, LINE-1 activity in rhesus macaque brain, and more.