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Thermo Fisher Scientific, AnaSpec, Waters, Rosetta Biosoftware

Thermo Fisher Scientific will launch the TSQ Vantage LC-MS/MS platform at the annual meeting of the American Society for Mass Spectrometry, the company said this week. The meeting will take place next week in Denver.
According to a statement from Thermo Fisher, the instrument is up to 10 times more sensitive than other triple-quadrupole instruments, but does not produce a commensurate increase in noise. As a result, greater reproducibility and precision in the analysis of peptides, as well as small molecules and biomolecules, can be achieved.
The TSQ Vantage uses a new S-Lens ion optics system to capture “virtually every ion and efficiently transfer it into the HyperQuad quadrupole mass analyzer,” the company said. The design is an advance over high-pressure, skimmer-based ion-source designs because it “eliminates mass discrimination and lowers the gas load on the expensive turbo-molecular pumps.” The design keeps the ion optical path clean longer while maintaining sensitivity.

AnaSpec introduced the SensoLyte 520 Cathespin S Assay Kit this week.
SensoLyte 520 is a homogeneous assay that can be used for the detection of cathespin S activity in biological samples or in purified enzyme preparations. A unique long wavelength 5-FAM/QXL 520 FRET peptide substrate is used in the kit, the company said in a statement.

Rosetta Biosoftware’s Elucidator has been enabled to mine Waters’ UltraPerformance LC, high-bandwidth proteomics discovery data, the companies said this week.
The software also can integrate Waters’ IdentityE search engine for secure protein identification.

Nonlinear Dynamics this week released version 3.0 of Progenesis SameSpots analysis software.
The new software offers typical analysis times of five minutes per image “and sets a new benchmark for 2D analysis in terms of speed, objectivity, and statistical power,” the company said in a statement. The software was used by the Human Proteome Organization in a study done by its Industry Advisory Board on reproducibility with 2D gel technology [See PM 11/15/07].

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.