Team Quantitates Phosphorylation Sites in Mice Sperm; May Lead to Male Contraceptive, Rxs | GenomeWeb

A team of investigators have used differential isotope labeling and mass spectrometry to identify 55 unique in vivo sites of phosphorylation and quantitated phosphorylation for 42 different phosphopeptides in murine sperm.

The work, which could provide a basis for the development of a male contraceptive and new drug therapies, "represents the first effort to determine which specific protein phosphorylation sites change their phosphorylation status in vivo as a result of the mammalian capacitation process," the researchers said.

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