Seeking Best of Both Worlds, Proteomics Researchers Pursue Middle-down Approach | GenomeWeb

As is well known, trypsin digest-based bottom-up workflows have dominated proteomics since the field's inception. More recently, top-down, intact protein approaches have gained ground, driven by instrument advances and increasing interest in analysis of post-translational modifications and protein isoforms.

Now, researchers are hoping to split the difference with middle-down proteomics, a method that aims to combine the best of both worlds.

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