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In Review: The Proteomics Push, Top PIs on Getting Grants, Catching Up with Last Year's Young Investigators, and More

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According to National Center for Biotechnology Information data published in Genome Technology one decade ago, GenBank contained 10,355,692,655 total base pairs comprising 9,102,634 sequences as of October 2000. Notes accompanying GenBank's October 2010 release show that it now contains 118,551,641,086 bases from 125,764,384 reported sequences.

GT's December 2000 issue also examined how proteomics researchers were beginning to do the heavy lifting at public and private institutions alike. At Celera Genomics, Steve Martin was "pioneering protein analysis" with a TOF/TOF mass spectrometer in hopes of propelling the firm to the forefront of the field. In another feature, GT contributor Nat Goodman considered the "uncharted frontier" that was post-Human Genome Project proteomics. "Lots of great ideas are competing to stake out the territory, but none has emerged to lead the charge," Goodman said at the time. After leaving Celera, Martin directed Applied Biosystems' Proteomics Research Center until 2004. Goodman, now a senior research scientist at the Institute for Systems Biology, is working to develop community databases for type 1 diabetes and Huntington's disease research.

Five years ago, the GT staff asked "Who's got grants?" and surveyed the work of several federal grantees. In 2005, Baylor College of Medicine's Richard Gibbs was funded $32.7 million to promote large-scale genomics research efforts at the school's Human Genome Sequencing Center. At the time, Gibbs told GT that grant applicants should always "believe in what you're doing — its importance, its value, and its probability of success." Gibbs and his colleagues have since published several clinically relevant genome sequences, including a catalog of reference genomes for the National Institutes of Health's Human Microbiome Project in Science in May.

And in the 2009 year-end issue, GT profiled 25 up-and-coming investigators, including Ryan Bailey at the University of Illinois at Urbana-Champaign, the National Human Genome Research Institute's Yardena Samuels, and Christine Wu at the University of Colorado School of Medicine. Bailey appeared on GT's September 2010 cover and Samuels and Wu also made news this year for their PI3K work and advances in quantitative proteomics, respectively.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.