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Recent Patents of Interest in Proteomics: Dec 13, 2007

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US Patent 7,307,059. Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water. Inventor: Marc Hellerstein; Assignee: The Regents of the University of California
 
Invention pertains to methods of measuring protein biosynthesis by using 2H2O or radioactive 3H2O
 

 
US Patent 7306672. Microfluidic-free interface diffusion techniques. Inventors: Carl Hansen; Stephen Quake; James Berger. Assignee: California Institute of Technology; The Regents of the University of California
 
The technique calls for a static fluid and a second fluid to be placed in contact along a microfluidic-free interface and “allowed to mix by diffusion without convective flow across the interface,” according to the abstract. In one embodiment, the fluids are static and initially positioned on either side of a closed valve structure in a microfluidic channel having a width that is tightly constrained in at least one dimension. The valve is opened and no-slip layers at the sides of the microfluidic channel suppress convective mixing between the two fluids along the resulting interface.
 

 
US Patent 7,305,331. System and method for simulating cellular biochemical pathways. Inventors: Eric Allen; Gilberto Fragoso; John Armstrong; Sandra Allen. Assignee: New World Science & Technology
 
The invention in particular pertains to the examination of pathways that underlie cellular functions, specifically signal transduction pathways. It relates to the prediction of functional properties of a protein, potential interaction partners of the protein, and potential target biochemical pathways in which the protein can interact.
 

 
US Patent 7,303,888. Mass spectrometric immunoassay. Inventors: Randall Nelson; Peter Williams; Jennifer Krone. Assignee: Intrinsic Bioprobes
 
Invention pertains to methods for the detection and quantification of antibody and antigen analytes using affinity capture to isolate the analytes and internal reference species. Mass spectrometric analysis of the analytes and internal reference species follows. Normalizing and calibrating obtained mass spectrum against the mass spectrum for an antibody or antigen of known concentration results in quantification.
 

 
US Patent 7,301,628. Method and apparatus for detecting biomolecular interactions. Inventors: Brian Cunningham; Peter Li; Frank DiFilippi. Assignee SRU Biosystems
 
The method described does not require labels and is high-throughput. The apparatus for detection biochemical interactions happening on the biosensor surface includes a light source.
 

 
US Patent 7,300,803. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor. Inventors: Bo Lin; Jane Pepper; Brian Cunningham; John Gerstenmaier; Peter Li; Jean Qiu; Homer Pien. Assignee: SRU
Biosystems
 
The method is high-throughput and also relates to optical devices.
 

 
US Patent 7,300,753. Immunoaffinity isolation of modified peptides from complex mixtures. Inventors: John Rush; Hui Zhang; Xiangming Zha; Michael Comb; Yi Tan. Assignee: N/A
 
The method described involves obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; contacting the preparation with at least one immobilized modification-specfic antibody; and isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody.

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