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Recent Patents of Interest in Proteomics: Oct 7, 2011

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Recent Patents of Interest in Proteomics

US Patent No. 8,031,925. Method and computer-program product for detecting and quantifying protein spots. Inventors: Jeffrey Morris, Howard Gutstein. Assignee: The Board of Regents of the University of Texas System

Covers a method and computer program for detecting and quantifying protein spots in a gel by taking a pixel-by-pixel average of a plurality of aligned gel images; using pinnacle detection to detect spots; and quantifying spots using the maximum intensity within fixed neighborhoods surrounding pinnacle locations.


US Patent No. 8,030,092. Controlled electrophoresis method. Inventors: Norberto Guzman. Assignee: Princeton Biochemicals

Covers an electrophoresis apparatus for sequentially analyzing a single sample or multiple samples using a large-bore transport capillary intersecting with smaller separation capillaries with antibody-based analyte concentrators installed at the respective intersections.


US Patent No. 8,030,089. Method of analyzing differential expression of proteins in proteomes by mass spectrometry. Inventors: Scott Geromanos, Ashok Dongre, Gregory Opiteck, Jeffrey Silva. Assignee: Micromass

Covers a method of identifying biological molecules using accurately determined mass-to-charge ratios and a further property such as elution time or charge state.


US Patent No. 8,030,083. Method of analyzing protein structural affinity relationship. Inventor: Yoshiya Oda. Assignee: Eisai

Covers a method of analyzing the structural affinity relationship between proteins and a compound using compound-immobilized carriers to purify proteins bound to the compound on the carrier and then analyzing these proteins using mass spectrometry.


US Patent No. 8,030,011. Biomarkers and assays for myocardial infarction. Inventors: Urban Kiernan, Dobrin Nedelkov, Randall Nelson. Assignee: Intrinsic Bioprobes

Covers blood-based biomarkers linked to cardiovascular disease that can be used for the determination of myocardial infarction.


US Patent No. 8,029,979. Method for determining the substrate specificity of an enzyme. Inventors: Jens Schneider-Mergener, Mike Schutkowski, Ulf Reimer, Liying Dong, Soren Panse, Dirk Scharn, Frank Osterkamp, Gerd Hummel, Laurence Jobron. Assignee: JPT Peptide Technologies

Covers a method of determining substrate specificity of enzymatic activity by generating an array of immobilized amino acid sequences; incubating an enzyme with the array; and detecting reactions by changes in the molecular weight of the amino acid sequences.


US Patent No. 8,024,282. Method for reliable classification of samples in clinical diagnostics using an improved method of classification. Inventors: Maxim Tsypin, Heinrich Roder. Assignee: Biodesix

Covers a system of classification of a test object using a training set comprising a plurality of objects, each of which is assigned as a member of a class, and wherein the objects in the training set are collectively members of at least two classes.


US Patent No. 8,021,895. Markers of renal transplant rejection and renal damage. Inventors: Stefan Kienle, Richard Joubert. Assignee: Electrophoretics Limited

Covers protein markers for renal damage and assays for detecting these markers.


US Patent No. 8,021,850. Universal tandem solid-phases based immunoassay. Inventor: Ribo Guo. Assignee: N/A

Covers an immunoassay that uses an affinity binding solid phase to capture an antigen from a fluid sample followed by dissociating the antigen and transferring and coating the antigen to a non-affinity binding solid phase for specific antigen determination.


US Patent No. 8,013,129. Protein separation device. Inventors: Heng Hang Tsai, Hon-Chiu Eastwood Leung. Assignee: Agency for Science, Technology and Research

Covers a protein separation device comprising a chaperone protein immobilized on a substrate.


US Patent No. 8,012,720. Protein detecting device. Inventors: Shozo Fujita, Shunsaku Takeishi, Tsuyoshi Fujihara. Assignee: Fujitsu Limited

Covers a device for protein detection that includes a detecting unit with a polynucleotide double strand for binding the target protein and an electrode section for detecting the change in electrical conductivity of the polynucleotide strand modified by the bound target protein.


US Patent No. 8,012,703. Microarrays and uses therefor. Inventors: James Hoeffler, Joseph Fernandez, Marc Nasoff. Assignee: Life Technologies

Covers the use of microarrays to measure protein expression by contacting an array of known or unknown antibodies on a solid surface with one or more proteins.


US Patent No. 8,012,693. Analysis of chemically crosslinked cellular samples. Inventors: Conklin Chong, E. Bathsheba, Patrick Parks. Assignee: 3M Innovative Properties

Covers a method of analyzing cellular samples that include a chemically crosslinked analyte, typically using mass spectrometry.


US Patent Nos. 8,012,434 and 8,007,745. Anti-clogging device and method for in-gel digestion applications. Inventors: Phillip Clark, Chris Scott, Marc Emerick, William Kopaciewicz, Donald Rising. Assignee: Millipore

Covers a proteomics sample preparation device and method for in-gel digestion of proteins to desalt and concentrate samples prior to analysis by MALDI-TOF or electrospray mass spectrometry. The device uses a number of wells linked to an outlet or drainage opening containing a three-dimensional structure comprising sorptive particles in a porous polymer matrix to enable solid phase extraction.


US Patent No. 8,008,094. Methods for analyzing interactions between proteins and sugar chains. Inventors: Jun Hirabayashi, Atsushi Kuno, Sachiko Nakamura, Noboru Uchiyama. Assignee: National Institute of Advanced Industrial Science and Technology

Covers a technique for optimizing the immobilization of proteins that interact with sugar chains onto a substrate as well as improving detection of interactions between sugar chains and lectins.


US Patent No. 8,007,725. Electrophoresis apparatus having valve system. Inventor: Norberto Guzman. Assignee: Princeton Biochemicals

Covers an electrophoresis apparatus for sequentially analyzing a single sample or multiple samples using a large-bore transport capillary intersecting with smaller separation capillaries with antibody-based analyte concentrators installed at the respective intersections.


US Patent No. 8,007,724. Electrophoresis apparatus having at least one auxiliary buffer passage. Inventor: Norberto Guzman. Assignee: Princeton Biochemicals

Covers an electrophoresis apparatus for sequentially analyzing a single sample or multiple samples using a large-bore transport capillary intersecting with smaller separation capillaries with antibody-based analyte concentrators installed at the respective intersections.


US Patent No. 8,003,934. Methods and apparatus for ion sources, ion control and ion measurement for macromolecules. Inventor: Andreas Hieke. Assignee: Andreas Hieke.

Covers methods, devices, processes, and other inventions related to ion sources for the analysis of macromolecules.


US Patent No. 8,003,333. Serum biomarkers for early detection of acute cellular rejection. Inventor: Michael Charlton. Assignee: Mayo Foundation for Medical Education and Research

Covers a method using measurement of at least one protein to diagnose organ transplant patients with acute cellular rejection.

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