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Recent Patents of Interest in Proteomics: Aug 19, 2011


Recent Patents of Interest in Proteomics

US Patent No. 8,000,904. Methods and products related to the improved analysis of carbohydrates. Inventors: Nishla Keiser, Carlos Bosques, Ram Sasisekharan, Pankaj Gandhe, Sasi Raguram, Aravind Srinivasan. Assignees: Momenta Pharmaceuticals, Massachusetts Institute of Technology

Covers methods of analysis of carbohydrates including N-glycans and O-glycans found on proteins, including use of glycosylation patterns in cells, tissues, and in body fluids for diagnostic and treatment purposes.

US Patent No. 7,999,080. Reagents for the detection of protein phosphorylation in signaling pathways. Inventors: Peter Hornbeck, Valerie Goss, Kimberly Lee, Ting-Lei Gu, Albrecht Moritz. Assignee: Cell Signaling Technology

Discloses novel phosphorylation sites in signal transduction proteins and pathways and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides for their detection and quantification.

US Patent No. 7,998,750. Mass spectrometry precursor ion selection. Inventors: Michael May, Jingwen Yao. Assignee: Shimadzu Research Laboratory

Covers a method of selecting precursor ions of a sample polypeptide along with methods for determining putative amino acid sequences for sample polypeptides.

US Patent No. 7,998,508. Method of screening placental proteins responsible for pathophysiology of preeclampsia, and marker for early diagnosis and prediction of preeclampsia. Inventors: Won Sun Park, Na Ri Kim, Jin Han. Assignee: Inje University Industry-Academic Cooperation Foundation

Covers a method of screening placental proteins for the early diagnosis and prediction of preeclampsia by isolating the proteins using 2D electrophoresis and comparing and analyzing the separated proteins from normal and preeclamptic samples.

US Patent No. 7,996,155. ANOVA method for data analysis. Inventor: Lee Weng. Assignee: Microsoft

Covers improved analysis of variance, or ANOVA, methods for analyzing measured and transformed data. The method is particularly useful for analyzing gene or protein expression data, according to the inventors.

US Patent No. 7,993,823. Biomarkers for toxic algae. Inventors: Samuel Lo, Leo Chan, John Hodgkiss. Assignee: The Hong Kong Polytechnic University

Covers biomarkers, including polypeptides, that can be used to identify algae species and strains as well as detect the presence of algal toxins.

US Patent No. 7,989,215. Methods and systems for adding a reagent to an analyte in a gel. Inventors: Jonas Astrom, Bengt Bjellqvist, Lars Fagerstam, Kristina Uhlen. Assignee: GE Healthcare Bio-Sciences

Covers a method of adding a reagent to an analyte in a gel and also of transferring liquid analyte reagent mixtures to a second vessel for purposes relating to the manipulation of biological molecules, particularly proteins and peptides in isoelectric focusing gels.

US Patent No. 7,985,843. Compositions and methods for the therapy and diagnosis of ovarian cancer. Inventors: Gary Fanger, Steven Fling. Assignee: Corixa

Covers biomarkers including polypeptides that are useful in the diagnosis of ovarian cancer.

US Patent No. 7,983,852. Methods of automated spectral peak detection and quantification without user input. Inventors: David Wright, Robert Grothe. Assignee: Thermo Finnigan (now Thermo Fisher)

Covers a method of automatically identifying and characterizing spectral peaks and reporting information relating to the peaks to a user with neither baseline model curve parameters nor peak model curve parameters input by nor exposed to the user prior to the reporting step.

US Patent No. 7,981,684. Methods and biomarkers for diagnosing and monitoring psychotic disorders. Inventors: Yishai Levin, Sabine Bahn. Assignee: Psynova Neurotech

Covers a method of diagnosing or monitoring a psychotic disorder by measuring the level of one or more protein biomarkers.

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US Patent No. 7,981,633. Method for measuring tyrosine kinase phosphorylation. Inventors: Tanja Henzler, Bjoern Hock, Andree Blaukat, Uwe Hofmann. Assignee: Merck

Presents dye-based methods for measuring the autophosphorylation of one or more tyrosine kinases and the use of these methods to profile kinase inhibitors and activators.

US Patent No. 7,979,214. Peptide identification. Inventors: Kristin Jarman, William Cannon, Kenneth Jarman, Alejandro Heredia-Langner. Assignee: Battelle Memorial Institute

Covers a method of identifying peptides from a list of candidates using collision-induced dissociation tandem mass spectrometry data by applying a probabilistic model for the occurrence of spectral peaks corresponding to frequently observed partial peptide fragment ions.

US Patent No. 7,977,626. Time of flight mass spectrometry method and apparatus. Inventors: August Hidalgo, Bryan Miller, Gregor Overney. Assignee: Agilent Technologies

Covers a method and apparatus for time-of-flight mass spectrometry wherein the sum of transients taken for generating a given spectrum is determined as a function of a characteristic of the incoming data for that spectrum.

US Patent No. 7,977,462. Tyrosine phosphorylation sites. Inventors: Peter Hornbeck, Ailan Guo, Ting-Lei Gu, Klarisa Rikova, Albrecht Moritz, Charles Farnsworth, Matthew Stokes, Jian Yu, Erik Spek, Yu Li, Anthony Possemato, Jessica Cherry, Valerie Goss, Jeffrey Mitchell, John Rush, Corinne Michaud. Assignee: Cell Signaling Technology

Discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia along with peptides containing the sites, antibodies to the sites, and their diagnostic and therapeutic uses.

US Patent No. 7,977,279. Differential phage capture proteomics. Inventor: Paul Stroobant. Assignee: Differential Proteomics

Covers methods for identifying, isolating, and comparing proteins in two complex biological samples using affinity chromatography and phage display techniques.

US Patent No. 7,976,779. Integrated LC-ESI on a chip. Inventor: Yu-Chong Tai, Jun Xie, Jason Shih, Terry Lee, Yunan Miao. Assignee: California Institute of Technology

Covers a microfluidic system with on-chip pumping that can be used for liquid chromatography and electrospray ionization mass spectrometry.

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.