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Recent Patents of Interest in Proteomics: Jul 8, 2011


Recent Patents of Interest in Proteomics

US Patent No. 7,973,134. Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways. Inventors: Albrecht Moritz, Kimberly Lee, John Rush, Roberto Polakiewicz. Assignee: Cell Signaling Technology

Discloses 211 novel phosphorylation sites in signal transduction proteins underlying anaplastic large cell lymphoma and provides phosphorylation-site-specific antibodies and heavy-isotope labeled peptides for their detection and quantification.

US Patent No. 7,972,827. Photoswitchable method for the ordered attachment of proteins to surfaces. Inventors: Julio Camarero, James DeYoreo, Youngeun Kwon. Assignee: Lawrence Livermore National Security

Covers a method of attaching proteins to any solid support with control over their orientation of attachment using UV-light activation. Enables the creation of protein arrays using standard photolithographic techniques.

US Patent No. 7,972,802. Lipoprotein-associated markers for cardiovascular disease. Inventors: Jay Heinecke, Tomas Vaisar. Assignee: University of Washington

Covers a method of screening mammalian subjects for one or more lipoprotein-associated biomarkers to determine if the subject is suffering from, or at risk of developing, cardiovascular disease.

US Patent No. 7,972,788. Skin aging marker and technique for use thereof. Inventors: Satoshi Miyata, Kaoru Miyazaki, Chie Yasuda, Akihiro Iwamatsu. Assignees: Fancl, Yokohama City University, Kihara Memorial Yokohama Foundation for the Advancement of Life Sciences, Kirin Holdings

Covers a system for determining the degree of skin aging based on methods including measuring expression levels of secretory and/or intracellular proteins.

US Patent No. 7,972,770. Methods of detection of cancer using peptide profiles. Inventors: Paul Tempst, Josep Villanueva. Assignee: Memorial Sloan-Kettering Cancer Center

Covers methods for identifying and monitoring cancer in a patient using serum peptide profiles determined by mass spectrometry.

US Patent No. 7,964,362. Proteome epitope tags and methods of use thereof in protein modification analysis. Inventors: Frank Lee, Xun Meng, David Livingston. Assignee: Millipore

Covers methods for detecting the presence of proteins, particularly those with various post-translational modifications, by use of one or more capture agents that interact with capture sequences uniquely characteristic of a set of proteins.

US Patent No. 7,964,077. Automated two-dimensional electrophoresis apparatus and instrument constituting the apparatus. Inventors: Yuji Maruo, Katsuyoshi Takahashi, Unuma, Keisuke Usui, Hideki Kinoshita, Kisho Shiseki, Yoshio Suzuki, Atsunori Hiratsuka, Hiroyuki Fukui, Kenji Yokoyama, Ichiji Namatame, Kouhei Yodoya, Yasuhiro Ogawa, Koji Sakairi, Chie Hayashida, Satonari Akutsu, Kazuyoshi Yano, Isao Karube. Assignees: Sharp, Toppan Printing Co.

Describes a sample separation device that enables the automation of two-dimensional electrophoresis resulting in improved reproducibility of results.

US Patent No. 7,956,321. Method of measuring target object in a sample using mass spectrometry. Inventors: Yohei Murayama, Manabu Komatsu, Hiroyuki Hashimoto. Assignee: Canon.

Covers a method for obtaining a high spatial resolution two-dimensional image of a target object in a sample using time-of-flight mass spectrometry.

US Patent No. 7,955,810. Positive selection of serum proteins for proteomic analysis. Inventors: David Agus, William Hillis. Assignees: Cedars-Sinai Medical Center, Applied Proteomics

Covers methods and kits for selection of species of interest from a biological sample based on peptide and protein sequences obtained using mass spectrometry. Also covers the use of nucleic acids to extract low-abundance proteins and peptides from a sample for analysis.

US Patent No. 7,951,279. Electrophoresis apparatus and device therefor. Inventors: Chie Hayashida, Koji Sakairi, Katsuyoshi Takahashi, Yuji Maruo, Michinobu Mieda, Yutaka Unuma. Assignees: Toppan Printing, Sharp

Describes an electrophoresis device that uses multiple sample storage sections to enable an operator to sample separated proteins without making contact with the electrophoresed gel.

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.