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Recent Patents of Interest in Proteomics: Mar 18, 2011


Recent Patents of Interest in Proteomics
US Patent No. 7,906,759. Mass spectroscopy system and mass spectroscopy method. Inventors: Naomi Manri, Takashi Baba, Hiroyuki Satake. Assignee: Hitachi High-Technologies.

Covers a tandem mass spectrometer system in which the sample is ionized at the desired polarity, fragment ions obtained by dissociating the ion are analyzed in the first or section mass spec section, the polarity of the second mass spec section is determined based on this analysis, and the mass spectroscopy is carried out.

US Patent No. 7,906,630. Method for identifying peptides in a biological sample. Inventors: Alvydas Mikulskis, Mary Lopez. Assignee: PerkinElmer.

Describes a method for isolating cargo peptides from samples containing cargo-peptide-carrier protein complexes by contacting the sample with a binding moiety selective for the carrier protein.

US Patent No. 7,906,342. Monitoring treatment of cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples. Inventors: Heinrich Roder, Maxim Tsypin, Julia Grigorieva. Assignee: Biodesix.

Covers the use of mass spec data and a classification algorithm to determine whether a patient with non-small-cell lung cancer, head and neck squamous cell carcinoma, or colorectal cancer has developed a non-responsiveness to treatment with a drug targeting an epidermal growth factor receptor pathway.

US Patent No. 7,906,301. Multiplex method for increased proteomic coverage from histopathologically processed biological samples, tissues, and cells. Inventors: David Krizman, Marlene Darfler. Assignee: Expression Pathology.

Cover methods for multiplex analysis of formalin-fixed tissue samples using liquid tissue preparations.

US Patent No. 7,901,942. Method of quantifying membrane protein by mass spectrometry using peptide selection criteria. Inventors: Junichi Kamiie, Sumio Otsuki, Tetsuya Terasaki. Assignee: Tohoku University.

Covers a technique for quantifying plasma membrane proteins using stable-isotope labeled peptides as probes in LC-MS/MS.

US Patent No. 7,901,901. Assays for measuring phosphate modification enzyme activity. Inventors: Qing-Fen Gan. Assignee: Roche Palo Alto.

Describes assays for measuring the activity of enzymes like kinases, phosphatases, cyclases, and phosphodiesterases that catalyze phosphate modifications.

US Patent No. 7,901,886. Microfluidic extraction method. Inventors: Cord Staehler, Peer Staehler, Manfred Mueller. Assignee: Febit Holding.

Covers an extraction method for isolating target molecules from a sample using a microfluidic carrier.

US Patent No. 7,897,405. Method for identifying the elution time of an analyte. Inventors: Amol Prakash. Assignee: Thermo Finnigan (now Thermo Fisher Scientific).

Covers a method for determining the elution time for peptides of interest from an LC column using chromatographic data obtained during selective-reaction monitoring experiments.

US Patent No. 7,892,761. Protein markers for diagnosing stomach cancer and the diagnostic kit using them. Inventors: Chul Woo Kim, Syng-Yup Ohn, Mi Young Han, Yong-Sung Shin. Assignee: Bioinfra.

Describes protein markers for diagnosing stomach cancer and a diagnostic kit using 2D gel electrophoresis and bioinformatics to confirm the expression levels of marker proteins whose expressions differ in stomach cancer patients from normal subjects.

US Patent No. 7,888,480. Reagents for the detection of protein phosphorylation in leukemia signaling pathways. Inventors: Roberto Polakiewicz, Valerie Goss; Albrecht Moritz, Ting-Lei Gu, Kimberly Lee. Assignee: Cell Signaling Technology.

Describes more than 280 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human leukemia along with phosphorylation-site-specific antibodies and heavy-isotope-labeled peptides for detection and quantification of those phosphorylation sites and proteins.

US Patent No. 7,888,135. Diagnostic assay for Trypanosoma cruzi infection. Inventors: Rick Tarleton, Ronald Etheridge. Assignee: University of Georgia Research Foundation.

Describes a diagnostic test for infection of T. cruzi, the causative agent of Chagas disease, including a method of screening T. cruzi polypeptides to identify antigenic polypeptides to be included as part of the test.

US Patent No. 7,883,858. Methods for identifying and monitoring drug side effects. Inventors: Leroy Hood, Biaoyang Lin. Assignee: Institute for Systems Biology.

Covers a method of detecting organ-specific protein expression patterns in order to identify drug side effects. Includes reagents and panels and arrays for determining organ-specific blood protein patterns.

US Patent No. 7,880,136. Multiple ion injection in mass spectrometry. Inventors: Alexander Makarov, Oliver Lange, Stevan Horning. Assignee: Thermo Finnigan (now Thermo Fisher Scientific).

Describes a method of mass spectrometry that includes: accumulating in an ion store a sample of one type of ions to be analyzed; accumulating in the ion store a sample of another type of ions to be analyzed; and mass analyzing the combined samples of the ions.

US Patent No. 7,879,620. Method and system for determining whether a drug will be effective on a patient with a disease. Inventors: Heinrich Roder, Maxim Tsypin, Julia Grigorieva. Assignee: Biodesix.

Covers a process for determining whether a patient will respond to a drug treatment by using a test spectrum produced via mass spec analysis of the patient's serum and comparing this spectrum to that of other subjects who have or have not responded to the drug.

US Patent No. 7,879,573. Isolation of analytes. Inventors: Wayne Patton, Thomas Miller, Nan Jiang, Michael O'Malley. Assignee: PerkinElmer.

Describes methods of detecting, isolating, and analyzing analytes including proteins, glycoproteins, and lipids for the discovery of novel biomarkers for various diseases.

The Scan

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.

Fragile X Syndrome Mutations Found With Comprehensive Testing Method

Researchers in Clinical Chemistry found fragile X syndrome expansions and other FMR1 mutations with ties to the intellectual disability condition using a long-range PCR and long-read sequencing approach.

Team Presents Strategy for Speedy Species Detection in Metagenomic Sequence Data

A computational approach presented in PLOS Computational Biology produced fewer false-positive species identifications in simulated and authentic metagenomic sequences.

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.