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Recent Patents of Interest in Proteomics: Jan 28, 2011

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US Patent No. 7,875,435. Diagnostic testing process. Inventors: David Marlborough, Andrew Sloane, Robert Cole, William Hunter. Assignee: Proteome Systems.

Covers a method and apparatus for a flow-through assay using a pre-incubation step in which the sample to be analyzed and a detection analyte bind together for a period of time before being put in contact with a capture analyte, improving the sensitivity of the assay and reducing the sample volume required.


US Patent No. 7,868,547. Determination of analyte characteristics based upon binding properties. Inventors: Darryl Pappin, Philip Ross, Steven Guertin. Assignee: DH Technologies Development.

Describes a method of determining the characteristics of an analyte based on binding properties using differential labeling reagents and mass analysis.


US Patent No. 7,867,775. Selection of head and neck cancer patients for treatment with drugs targeting EGFR pathway. Inventors: Heinrich Roder, Maxim Tsypin, Julia Grigorieva. Assignee: Biodesix.

Covers the use of mass spec data and a classification algorithm to determine whether a head and neck squamous cell carcinoma patient is likely to benefit from therapy targeting an epidermal growth factor receptor pathway.


US Patent No. 7,867,755. Method for analyzing proteins. Inventors: Thomas Joos, Dieter Stoll. Assignee: NMI Naturwissenschaftliches und Medizinisches Institut an der Universitat Tubingen.

Describes a technique for using an array of capture molecules specific to peptide epitopes to detect and analyze proteins in a mixture.


US Patent No. 7,865,312. Method of non-targeted complex sample analysis. Inventors: Burke Goodenowe. Assignee: Phenomenome Discoveries.

Covers a method of non-targeted analysis of complex samples using a Fourier transform ion cyclotron mass spectrometer to obtain data on molecules in the sample and then comparing this data to a database containing identifying data of known molecules.


US Patent No. 7,858,928. Nanostructured surfaces as a dual ionization LDI-DESI platform for increased peptide coverage in proteomic analysis. Inventor: Daniel Knapp. Assignee: The United States of America Department of Health and Human Services.

Covers methods and devices for analyzing proteins using a gold-coated nanoporous alumina surface for dual ionization mode mass spec analysis using combined desorption electrospray ionization and laser desorption ionization to give increased sequence coverage.


US Patent No. 7,858,560. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions. Inventor: Hubert Koster, Suhaib Siddiqi, Daniel Little. Assignee: Caprotec Bioanalytics.

Describes collections of multifunctional capture compound reagents that allow for the isolation of classes of molecules in complex protein mixtures. Also includes automated systems for performing the method.


US Patent No. 7,858,392. Method and apparatus for processing of biological samples for mass spectrometry analysis. Inventors: Nelli Taranenko, Berk Oktem, Appavu Sundaram, Vladimir Doroshenko. Assignee: Science and Engineering Services.

Covers a system of processing biological samples before mass spec analysis that includes a device for applying a solution to the sample capable of partial digestion of target proteins into peptides.


US Patent No. 7,858,390. Selection of colorectal cancer patients for treatment with drugs targeting EGFR pathway. Inventors: Heinrich Roder, Maxim Tsypin, Julia Grigorieva. Assignee: Biodesix.

Covers the use of mass spec data and a classification algorithm to determine whether a colorectal cancer patient is likely to benefit from therapy targeting an epidermal growth factor receptor pathway.


US Patent No. 7,858,389. Selection of non-small-cell lung cancer patients for treatment with monoclonal antibody drugs targeting EGFR pathway. Inventors: Heinrich Roder, Maxim Tsypin, Julia Grigorieva. Assignee: Biodesix.

Covers the use of mass spec data and a classification algorithm to determine whether a non-small-cell lung cancer patient is likely to benefit from therapy targeting an epidermal growth factor receptor pathway.


US Patent No. 7,858,071. Biomarkers for amyotrophic lateral sclerosis. Inventors: Robert Bowser, Srikanth Ranganathan. Assignee: University of Pittsburgh.

Describes a method for diagnosing amyotrophic lateral sclerosis by analyzing proteins in a patient sample using mass spectrometry.


US Patent No. 7,855,057. Protein splice variant/isoform discrimination and quantitative measurements thereof. Inventors: Neal Gordon, James Graham. Assignee: Millipore.

Covers methods, reagents, and devices for detecting protein isoforms in a sample using combinations of capture agents unique to the protein variant to be measured.

The Scan

Shape of Them All

According to BBC News, researchers have developed a protein structure database that includes much of the human proteome.

For Flu and More

The Wall Street Journal reports that several vaccine developers are working on mRNA-based vaccines for influenza.

To Boost Women

China's Ministry of Science and Technology aims to boost the number of female researchers through a new policy, reports the South China Morning Post.

Science Papers Describe Approach to Predict Chemotherapeutic Response, Role of Transcriptional Noise

In Science this week: neural network to predict chemotherapeutic response in cancer patients, and more.