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Recent Patents of Interest in Proteomics: Dec 17, 2010


US Patent No. 7,851,749. Method for obtaining information and device therefore. Inventors: Manabu Komatsu, Hiroyuki Hashimoto, Yohei Murayama, Kazuhiro Ban. Assignee: Canon.

Describes a method for obtaining information on the mass of an object using time-of-flight mass spectrometry that includes placing colloidal metal particles to promote ionization of the object inside the object and irradiating the object with a primary beam.

US Patent No. 7,851,230. Stress-induced phosphoprotein 1 as a biomarker for the detection of human ovarian cancers and endometriosis. Inventors: Tzu-Hao Wang, Shun-Hua Chen. Assignee: Chang Gung Memorial Hospital (Taiwan).

Covers a method for the detection, preliminary screening, or monitoring of ovarian cancers and endometriosis using STIP1 as a biomarker for the condition.

US Patent No. 7,851,172. Biomarkers of mild cognitive impairment and Alzheimer's disease. Inventors: Mark Lovell, Bert Lynn. Assignee: University of Kentucky Research Foundation.

Covers the use of at least one of a transthyretin and/or prostaglandin-H2 D-isomerase protein, and at least one other different protein selected from a transthyretin, prostaglandin-H2 D-isomerase, beta-2-microglobulin, cystatin C, superoxide dismutase [Cu--Zn], plasma retinol-binding protein, phosphatidylethanolamine-binding protein, carbonic anhydrase 2, prostaglandin-H2 D-isomerase, and/or serotransferrin protein to determine mild cognitive impairment or Alzheimer's status.

US Patent No. 7,850,835. Solution phase electrophoresis device, components, and methods. Inventors: Joseph Amshey, Timothy Updyke, Thomas Jackson, Michael Thacker. Assignee: Life Technologies.

Describes a device for fluid phase electrophoresis – particularly for solution phase isoelectric focusing.

US Patent No. 7,846,748. Methods of quantitation and identification of peptides and proteins. Inventor: Christoph Borchers. Assignee: The University of North Carolina at Chapel Hill.

Provides methods of quantifying the amount or concentration of peptides and/or proteins in one or more samples using differentially isotopically labeled peptides and/or proteins, as well as methods for identifying the peptides and proteins in the samples.

US Patent No. 7,842,517. Method and compositions for the detection of protein glycosylation. Inventors: Linda Hseih-Wilson, Nelly Khidekel, Hwan-Ching Tai, Sabine Arndt. Assignee: California Institute of Technology.

Provides methods for the detection of post-translationally modified proteins and glycosylated proteins in particular. The technique uses an engineered mutant of beta-1,4-galactosyltransferase to transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins, which then serves as a biotin handle, enabling detection of the modified protein.

US Patent No. 7,842,344. Peptide and protein arrays and direct-write lithographic printing of peptides and proteins. Inventors: Chad Mirkin, Jung-Hyurk Lim, David Ginger, Jwa-Min Nam, Ki-Bum Lee, Linette Demers, Albena Ivanisevic. Assignee: Northwestern University.

Covers an invention related to the use of direct-write lithographic printing of proteins and peptides using nanoscopic tips to create protein and peptide arrays.

US Patent No. 7,838,826. Apparatus and method for parallel flow ion mobility spectrometry combined with mass spectrometry. Inventor: Melvin Park. Assignee: Bruker Daltonics.

Covers a device and method for parallel flow ion mobility spectrometry prior to analysis by a mass analyzer. Ions subjected to an RF quadrupole field, movements of the carrier gas, and an axial DC field are separated on the basis of their mobilities.

US Patent No. 7,833,625. Materials, methods and systems for separating and identifying proteins from mixtures. Inventors: Egisto Boschetti, Pier Giorgio Righetti. Assignee: Bio-Rad Laboratories.

Describes a system and methods for isolating and identifying components of a mixture based upon their different isoelectric points.

US Patent No. 7,829,845. Methods and instruments for identification of glycosylated proteins and peptides. Inventors: Kisaburo Deguchi, Atsumu Hirabayashi, Hiroki Ito, Takashi Baba. Assignee: Hitachi High-Technologies.

Covers the use of negative-ion CID and positive-ion ECD in analyzing glycans and peptide sequences without requiring the glycans to be liberated from the glycosylated peptides.

US Patent No. 7,829,841. Mass spectrometer. Inventors: Robert Bateman, Kevin Giles, Steven Pringle, Jason Wildgoose. Assignee: Micromass UK (Waters).

Describes a mass spectrometer comprising an ion mobility spectrometer or separator and an ion guide that maintains the fidelity and/or composition of ions received from the ion mobility spectrometer along the length of the guide.

The Scan

Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients

Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.

Study Points to Synonymous Mutation Effects on E. Coli Enzyme Activity

Researchers in Nature Chemistry saw signs of enzyme activity shifts in the presence of synonymous mutations in a multiscale modeling analysis of three Escherichia coli genes.

Team Outlines Paternal Sample-Free Single-Gene Approach for Non-Invasive Prenatal Screening

With data for nearly 9,200 pregnant individuals, researchers in Genetics in Medicine demonstrate the feasibility of their carrier screening and reflex single-gene non-invasive prenatal screening approach.

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.