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Recent Patents of Interest in Proteomics: Mar 6, 2008

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US Patent 7,336,812. System for microvolume laser scanning cytometry. Inventors: Louis Dietz Ian Walton; Chih-Hua Chung; Scott Norton; James Winkler; Aaron Kantor; Byron Lee; Shalom Tsur. Assignee: PPD Biomarker
 
Invention pertains to an integrated system for biological marker identification. The system uses microvolume laser scanning microscopy to measure expression of biological markers in fluids and includes instrumentation for performing MLSC and improved particle detection and analysis methods. The system comprises an informatics architecture “for the analysis of data obtained from the MLSC in tandem with other medical information,” according to the abstract.
 

 
US Patent 7,335,486. Method for universal enzymatic production of bioactive peptides. Inventors; Fred Wagner; Peng Luan; Yuannan Xia; Daniel Strydom; Edwin Merrifield; Mary Bossard; Barton Holmquist; Jin Seog Seo. Assignee: Restoragen
 
Provided are methods for making peptides from a polypeptide containing one or more copies of the peptide using clostripain to excise the peptide from the polypeptide.
 

 
US Patent 7,335,478. Reactivation-based molecular interaction sensors. Inventors: Robert Balint; Jeng-Horng Her. Assignee; KaloBios Pharmaceuticals
 
Invention pertains to methods and systems for “linking the functional activation of a responder molecule to the interaction of two or more binding ensemble members of interest,” according to the abstract. This may be done in vitro or in vivo,” producing a signal, phenotype, or other functional output in response to the interaction of the binding ensemble members.”
 

 
US Patent 7,333,896. Quality assurance/quality control for high-throughput bioassay process. Inventors: Ben Hitt; Peter Levine; Emanuel Petrocoin. Assignee: Correlogic Systems
 
A method is described that includes generating a bioassay process model, comparing spectral data based on a combination of a biochip and test serum to the bioassay process model to test whether the test sample and bioassay process are producing acceptable data. “Alternatively, the method may include comparing spectral data based on a combination of serum and diluents used in an electrospray process to the bioassay process model,” according to the abstract. If the bioassay process and test sample fall within the model, the produced spectrum can by analyzed further.
 

 
US Patent 7,333,895. Quality assurance for high-throughput bioassay methods. Inventors: Ben Hitt; Peter Levine; Timothy Coleman. Assignee: Correlogic Systems
 
The methods described allow for the monitoring of an entire system for obtaining spectral data from biological samples. The method includes generation of a bioassay process model, comparing a test sample against the bioassay process model.
 

 
US Patent 7,32,355. Method and compositions for the detection of protein glycosylation. Inventors: Linda Hsieh-Wilson; Nelly Khidekel; Hwan-Ching Tai; Sabine Arndt. Assignee: California Institute of Technology
 
Methods described in the invention can be used to detect O-GlcNAc- post-translational modifications on proteins that other techniques could not detect, the authors say in the abstract.
 

 
US Patent 7,332,299. Endomannosidases in the modificaion of glycoproteins in eukaryotes. Inventor: Stephen Hamilton. Assignee: GlycoFi
 
Invention pertains to methods of modifying the glycosylation structures of recombinant proteins expressed in fungi and other lower eukaryotes to resemble more closely the glycosyation of proteins from higher mammals, in particular, humans. It also relates to novel enzymes and nucleic acids encoding them and hosts ”engineered to express the enzymes, methods for producing modified glycoproteins in hosts and modified glycoproteins so produced,” according to the abstract.
 

 
US Patent 7,332,296. Screening assay for enzymes involved in pathophysiology using SELDI-TOF mass spectrometry. Inventors: Khalid Elased; Mariana Morris. Assignee: Wright State University
 
The methods described relate to the quantification of enzymatic activity of an enzyme with a known substrate. The methods are suitable for assaying aspects of the rennin-angiotensis system and may be used to evaluate and/or monitor biological conditions associated with the rennin-angiotensis system “prior to the manifestation of known physiological and biomarkers for such conditions,” according to the abstract.
 

 
US Patent 7,332,286. Peptide or protein microassay method and apparatus. Inventors: Scott Diamond. Assignee: University of Pennsylvania
 
Invention pertains to a peptide or protein microassay method and apparatus in which a “wide variety of choromogenic or fluorogenic peptide or protein substrates … are individually suspended or dissolved in a hydrophilic carrier with aliquots of each substrate … deposited in an array or microarray of reaction loci…” according to the abstract. Each dot provides an individual reaction vessel containing the peptide or protein of interest, and biological samples may be applied to each dot for assay purposes.
 

 
US Patent 7,332,268. Layered support sheet for high-yield spot cutting from gels or membranes. Inventors: Kevin Thornton; Randy Gordon-Gilmore; Dan McEachern. Assignee: Bio-Rad Laboratories
 
By interposing a relatively pliable, intermediate layer on the side of the surface facing the gel or membrane, the excision of sample spots by pressing a cutting tool terminating in a hollow cylinder against the gel or membrane supported on a rigid surface can be made more reliable.
 

 
US Patent 7,331,511. Biopolymeric array scanners capable of automatic scale factor selection for a plurality of different dyes, and methods for making and using the same. Inventors: John Corson; Scott Connell; Srinka Ghosh. Assignee: Agilent Technologies
 
Invention provides biopolymeric array scanners capable of automatically selecting a dye-specific scale factor “to employ for a plurality of different dyes, as well as methods for making and using the same,” according to the abstract. Methods for obtaining collections of nominal scale factors and computer-readable mediums comprising the same are also provided.

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.