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Recent Patents of Interest in Proteomics: Nov 5, 2010

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US Patent No. 7,820, 961. Mass spectrometer and mass spectrometry method. Inventors: Masuyuki Sugiyama, Yuichiro Hashimoto, Hideki Hasegawa, Izumi Waki. Assignee: Hitachi.

Describes a linear trap mass spectrometer that has high ejection efficiency and low ejection energy. The mass spectrometer has quadrupole rod structure applied with RF voltage into which ions are introduced and ejected mass selectively.


US Patent No. 7,820,803. Immobilized phosphatidic acid probe. Inventors: Len Stephens, Phillip Thomas Hawkins, Andrew Bruce Holmes, Maria Manifava, Ze-Yi Lim, Nicholas Ktistakis, Johannes Thuring, John Fitzgerald Wilhelmus. Assignee: Andrew Bruce Holmes, Ze-Yi Lim, John Fitzgerald Wilhelmus.

Covers immobilized phosphatidic acid probes that can be used in the identification of proteins important in signal transduction, housekeeping, and the diagnosis of disease.


US Patent No. 7,820,396. Method for determining atopic dermatitis using protein marker. Inventors: Satoshi Miyata, Kaoru Miyazaki, Chie Yasuda, Akihiro Iwamatsu, Zenro Ikezawa, Michiko Aihara, Kayano Moriyama. Assignee: Fancl Corporation.

Covers protein biomarkers for atopic dermatitis as well as a method for determining the degree of inflammation of atopic dermatitis and the risk of developing atopic dermatitis. Also covers methods for determining substances that are effective in treatment and prevention of the condition.


US Patent No. 7,820,023. Preconcentration interface coupling liquid chromatography to capillary electrophoresis. Inventor: Mario Curcio. Assignee: Roche Diagnostics

Protects an arrangement for a two-dimensional separation of complex analyte mixtures that includes an area between the two separation devices arranged for the concentration of individual sample fractions or components by applying a voltage between two electrodes with polarity opposite the charge of the components in the fraction.


US Patent No. 7,816,098. Methods of making and using a protein array. Inventors: Jonathon Michael Blackburn, John David Sutherland, Mitali Samaddar, Michelle Ann Mulder, Roland Kozlowski. Assignee: Sense Proteomic Limited.

Describes methods for the preparation of protein arrays using full length proteins and the use of these arrays for screening purposes.


US Patent No. 7,816,095. Biomarkers and assays for myocardial infarction. Inventors: Urban Kiernan, Dobrin Nedelkov, Randall Nelson. Assignee: Intrinsic Bioprobes.

Covers plasma/serum biomarkers for the determination of myocardial infarction as well as a multiplexed, mass spectrometric immunoassay capable of assaying for these biomarkers. Also includes methods for evaluating data generated using the biomarkers and further use of the assay for clinical, diagnostic, and therapeutic purposes.


US Patent No. 7,816,082. Methods of identifying pancreatic cancer cells. Inventors: Haiyong Han, Robert Gillies, David Morse, Victor Hruby. Assignees: The Arizona Board of Regents on behalf of the University of Arizona, The Translational Genomics Research Institute.

Describes a method of identifying pancreatic cancer cells based on the differential expression of combinations of target molecules. The method covers measuring the expression of three or more specific target molecules in combination and using these measurements to identify pancreatic cancer cells.


US Patent No. 7,811,973. Phage display technologies. Inventors: Roberto Burioni, Massimo Clementi. Assignee: Ribovax Biotechnologies.

Protects a technology for producing and screening fusion proteins on the surface of a filamentous phage using a single vector to generate cell and phage libraries containing a given series of protein sequences fused to one of two phage coat proteins.


US Patent No. 7,811,828. Method for identifying and quantifying of tumor-associated [peptides]. Inventors: Claudia Lemmel, Hans-Georg Rammensee. Assignee: Immatics Biotechnologies.

Covers a method for identifying and quantifying peptides associated with tumors through the use of stable-isotope labeling and the use of these peptides for the treatment of tumors and adenomatous diseases, including a pharmaceutical composition that contains at least one of the peptides.


US Patent No. 7,811,772. Apolipoprotein A-II isoform as a biomarker for prostate cancer. Inventors: John Semmes, Gunjan Malik, Michael Ward. Assignee: Eastern Virginia Medical School.

Covers the use of the protein ApoA-II isoform as a biomarker for determining prostate cancer status in patients with normal prostate-specific antigen. The biomarker can be detected by SELDI mass spectrometry, HPLC, PAGE, and Western blotting.


US Patent No. 7,811,436. Electrophoresis apparatus having an outlet passage. Inventors: Norberto Guzman. Assignee: Princeton Biochemicals.

Discloses an electrophoresis device featuring a large-bore transport capillary intersecting with a number of small-bore separation capillaries with analyte concentrators possessing antibody-specific chemistries stationed at these intersections to bind to one or more analytes of interest.


US Patent No. 7,807,789. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways. Inventors: Ailan Guo, Kimberly Lee, Klarisa Rikova, Charles Farnsworth, Albrecht Moritz, Yu Li, Robert Polakiewicz. Assignee: Cell Signaling Technology.

Describes 168 phosphorylation sites on signal transduction proteins along with phosphorylation-site-specific antibodies and heavy-isotope labeled peptides for the detection and quantification of these phosphorylated sites and proteins as well as methods for using these reagents for that purpose.


US Patent No. 7,807,182. Early detection of mycobacterial disease using peptides. Inventors: Suman Laal, Susan Zolla-Pazner, John Belisle. Assignees: Colorado State Research Foundation, New York University.

Covers the use of Mtb antigenic proteins and peptides in immunoassays for early detection of TB in patients as well as antigenic compositions, kits, and methods useful in detection of the disease.

The Scan

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.

Gut Microbiomes Allow Bears to Grow to Similar Sizes Despite Differing Diets

Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods.

Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.