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Recent Patents of Interest in Proteomics: Aug 20, 2010


US Patent 7,777,505. Nanopore platforms for ion channel recordings and single molecule detection and analysis. Inventors: Henry White, Ryan White, Eric Ervin. Assignee: University of Utah Research Foundation

The invention is a nanopore device that allows sensing entities such as protein ion channels to be inserted and removed, allowing for a potentially portable system using ion channels for applications like biosensing and drug development.

US Patent 7,776,550. Diagnosis of liver pathology through assessment of protein glycosylation. Inventors: Timothy Block, Mary Ann Comunale, Anand Mehta. Assignee: Philadelphia Health & Education Corporation

Covers methods for using fucosylation levels on proteins in biological fluids to diagnose pathologies of the liver. Includes methods for quantifying fucosylation as well as comparing the detected levels to reference values of fucosylation in healthy and diseased individuals.

US Patent 7,776,533. Compositions and methods for detection and isolation of phosphorylated molecules. Inventors: Brian Agnew, Joseph Beechem, Kyle Gee, Richard Haugland, Thomas Steinberg, Wayne Patton. Assignee: Life Technologies

Relates to phosphate-binding compounds that bind, detect, and isolate phosphorylated target molecules and their use in isolation of phosphorylated target molecules from complex mixtures for identifying kinase and phosphatase substrates and enzymes for proteomic analysis.

US Patent 7,776,341. Biomarkers of tuberculosis that distinguish disease categories: use as serodiagnostic antigens. Inventors: John Belisle, Mark Sartain, Suman Laal. Assignee: Colorado State University Research Foundation, New York University

Covers mycobacterial proteins useful in the early diagnosis of mycobacterial disease, including four proteins previously recognized as B cell antigens. Includes these proteins in various combinations with each other and one or more of a set of 10 additional proteins. Also covers methods and kits for using these proteins as biomarkers for mycobacterial disease detection.

US Patent 7,771,955. Affinity membrane for capture of a target biomolecule and formation thereof by site-directed immobilization of a capture biomolecule. Inventors: Timothy Alan Barbari, Sufi Rizwan Ahmed. Assignee: University of Maryland

Covers a method of directing an immobilized capture molecule on a hydrophobic membrane so as to maximize the biomolecule's binding activity.

US Patent 7,765,068. Identification and characterization of protein fragments. Inventors: Neil Kelleher, Gregory Taylor. Assignee: University of Illinois

The invention allows for the characterization of protein fragments from a sequence database by collecting a tandem mass spectrometry spectrum of the protein fragment and then using the intact mass in combination with fragment ion masses.

US Patent 7,764,361. Systems and methods to analyze multiplexed bead-based assays using backscattered light. Inventors: David Kelso, Abhishek Mathur. Assignee: Northwestern University

Covers a system and method for using an epifluorescence microscope-based optical system to localize microspheres in bead-based assays based on a back-scattered light image.

US Patent 7,759,130. Mass spectrometric quantitation method for biomolecules based on metabolically labeled internal standards. Inventors: Yoshiya Oda, Yasushi Ishihama, Tsuyoshi Tabata. Assignee: Eisai R & D Management

The method allows for the absolute quantification of biological molecules in a complex sample via mass spectrometry by including an isotope-labeled biological molecule as an internal standard.

The Scan

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.

Estonian Biobank Team Digs into Results Return Strategies, Experiences

Researchers in the European Journal of Human Genetics outline a procedure developed for individual return of results for the population biobank, along with participant experiences conveyed in survey data.

Rare Recessive Disease Insights Found in Individual Genomes

Researchers predict in Genome Medicine cross-population deletions and autosomal recessive disease impacts by analyzing recurrent nonallelic homologous recombination-related deletions.

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.