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Recent Patents of Interest in Proteomics: Jul 16, 2010

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US Patent 7,756,646. Method for predicting peptide detection in mass spectrometry. Inventors: Lars Kangas, Richard Smith, Konstantinos Petritis. Assignee: Battelle Memorial Institute

Covers a method for using repeated mass spectrometry analysis of a sample containing peptides from proteins with known amino acids to generate an algorithm capable of calculating the probability that a hypothetical peptide in a sample will be detected by a mass spec-based proteomic platform.


US Patent 7,754,861. Method for purifying proteins. Inventors: Egisto Boschetti, Lee Lomas. Assignee: Bio-Rad Laboratories

Covers a method and kits for purifying target proteins by contacting a sample of at least 95 percent target protein with a library of binding moieties which bind the contaminating proteins and a minority of target proteins to leave a purer sample of target proteins.


US Patent 7,749,774. Arrays formed of encoded beads having ligands attached. Inventors: Michael Seul.

The invention allows for interactive control over the creation and placement of planar arrays of biomolecules and the manipulation of the array shape and size, enabling sample preparation and handling for diagnostic and biochemical arrays.


US Patent 7,749,769. Simultaneous sequence analysis of amino- and carboxy-termini. Inventors: Donald Hunt, Joshua Coon, John Edward Philip Syka. Assignee: University of Virginia Patent Foundation

Covers a method for identifying polypeptides based on analysis of the amino acid sequence of the carboxy and amino via mass spectrometry.


US Patent 7,749,723. Universal readout for target identification using biological microarrays. Inventors: Ye Fang. Assignee: Corning Incorporated

Covers a method for performing an indirect competitive binding assay on a microarray to screen for compounds of interest. Uses binding kinetics and steric interference between targets of interest and universal readout units for different binding sites within the confines of a microspot.


US Patent 7,747,048. Method of analyzing separation patterns. Inventors: Ian Morns, Anna Kapferer, David Bramwell. Assignee: BioSignatures

Covers the analysis of protein sample separation patterns by producing a plurality of patterns, forming a representation of each pattern, building an importance map, and processing the importance map to identify regions of separation pattern that are statistically important in predicting a classification of the pattern.


US Patent 7,744,762. Microfluidic devices and methods facilitating high-throughput, on-chip detection and separation techniques. Inventors: Iuliana Lazar. Assignee: Virginia Tech Intellectual Properties

The invention comprises a microfluidic device that orthogonally transfers separated components from a separation channel into an array of microreservoirs, enabling direct analyte detection and high-throughput analysis.


US Patent 7,741,062. Epitope-captured antibody display. Inventors: William Dower, Steven Cwirla. Assignee: XenoPort

The method uses phage-display technology to bind target proteins within protein samples either individually or as part of a library or array. Target proteins can be identified by determining the sequence of the segment of heterologous nucleic acid encoding an epitope shared by the protein expressed by the phage-display system and the target protein.


US Patent 7,736,905. Method and system for determining whether a drug will be effective on a patient with a disease. Inventors: Heinrich Roder, Maxim Tsypin, Julia Grigorieva. Assignee: Biodesix

Covers a method for determining whether a patient with a disease or disorder will respond to drug therapy by analyzing patient serum using mass spectrometry and comparing the patient's serum to that of other patients at similar clinical stages that are known to have responded or not responded to the drug.


US Patent 7,736,480. Multi-dimensional electrophoresis method. Inventors: Norberto Guzman. Assignee: Princeton Biochemicals

The invention comprises an electrophoresis apparatus comprising a large-bore transport capillary intersecting with a plurality of small-bore separation capillaries with analyte concentrators at the intersection of these capillaries, which allows for multi-dimensional separation of analytes.

The Scan

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.

Tibetan Study Finds Adaptive Variant Influencing Skin Pigmentation

With a combination of phenotyping and genetic data, researchers document at PNAS a Tibetan-enriched enhancer variant influencing melanin synthesis and ultraviolet light response.

Domestication Linked to Nervous System Genes in Inbred Mouse Strains

Researchers highlighted more than 300 positively selected genes in domesticated mice, including genes linked to nervous system function or behavior in Genome Biology.

ALS Genetic Testing May Be Informative Across Age Ranges, Study Finds

Researchers in the journal Brain identified clinically actionable variants in a significant subset of older ALS patients, prompting them to point to the potential benefits of broader test use.