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Recent Patents of Interest in Proteomics: Apr 16, 2010

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US Patent 7,693,665. Identification of modified peptides by mass spectrometry. Inventors: Xiangping Zhu; Stephen J. Hattan; Xunming Chen; Ioannis A. Papayannopoulos. Assignee: Applied Biosystems, MDS [together now known as AB Sciex]

Covers methods for identifying the presence of modified peptides "using, at least in part, mass spectrometric signals from metastable ions that are formed in the field-free region of the analyzer," according to the patent's abstract. In various aspects, methods are provided using MS/MS data from two or more modified peptides, de-modified peptides, and non-modified peptides "by comparing the sequence and/or site of modification information for two or more of these three forms of a peptide."


US Patent 7,692,798. Method for biomolecular detection and system thereof. Inventors: Christopher C. Striemer; Andrew J. Murnan; Nestor O. Farmiga. Assignee: Adarza Biosystems

Covers a method for sensing one or more targets on a receptor having a substrate and a translucent coating. The method described includes minimizing interference fringe patterns in an image of the target and passing the image of the target through an imaging system between the receptor and detector.


US Patent 7,692,219. Ultrasensitive biosensors. Inventor: James W. Holm-Kennedy. Assignee: University of Hawaii

Pertains to a biosensor apparatus that includes a substrate, a source on one side of the substrate, a drain spaced from the source, a conducting channel between the drain and the source, an insulator region, and receptors "on a gate region for receiving target material," according to the patent's abstract.


US Patent 7,691,645. Immunosubtraction method. Inventors: Leigh N. Anderson; Rembert Pieper. Assignee: Agilent Technologies

Covers a method for removing abundant proteins from a sample. "The removal is accomplished by immunosubtraction of several high abundance, interfering, or contaminating proteins simultaneously," according to the patent's abstract.


US Patent 7,691,643. Mass analysis method and mass analysis apparatus. Inventors: Hiromichi Yamashita; Yoshiaki Kato. Assignee: Hitachi High-Technologies

Provides a mass analysis method and apparatus for identifying proteins and peptides at high speed and with improved accuracy. The method comprises selection of predetermined information from a database containing information about proteins and peptides; estimating the mass of the selected component and calculating frequency information for each mass; analysis of the sample using the apparatus to acquire a mass spectrum; selecting a mass for identification, based on the acquired mass spectrum and frequency information; performing mass analysis using the mass spectrum of the selected mass as a precursor ion; and identification using a resultant mass spectrum.


US Patent 7,684,934. Pattern recognition of whole cell mass spectra. Inventors: Alexandre Shvartsburg; Jon G. Wilkes; Paul Chiarelli; Ricky D. Holland; Dan A. Buzatu; Michael A. Beaudoin. Assignee: The United States of America as represented by the Department of Health and Human Services

Covers a method for the reproducible analysis of mass spectra from different sample sources. The complex spectra are deconvoluted by collapsing multiple peaks of different molecular mass originating from the same molecular fragment into a single peak. "The differences in molecular mass are apparent differences caused by different charge states of the fragment and/or different metal ion adducts and/or reactant products of one or more of the charge states," according to the patent's abstract. The deconvoluted spectrum is compared to a library of mass spectra from samples of known identity.


US Patent 7,678,883. Solubility tags for the expression and purification of bioactive peptides. Inventors: Qiong Cheng; Linda Jane Decarolis; Stephen R. Fahnestock; Tanja Maria Gruber; Lisa Diane Reiss; Pierre E. Rouviere. Assignee: E.I. Du Pont de Nemours

Covers peptide tags "useful for the generation of insoluble fusion peptides," according to the patent's abstract. The fusion peptides comprise at least one peptide tag "operably linked to a peptide of interest." When the fusion peptide in a host cell is expressed, a product that is insoluble and contained within inclusion bodies in the cell and/or cell lysate results. The peptides can then be purified and the protein of interest can be isolated after cleavage from the peptide tag.


US Patent 7,678,539. Arrays of biological membranes and methods and use thereof. Inventors: Ye Fang; Anthony G. Frutos; Steven J. Jonas; Peter J. Kalal; Joydeep Lahiri. Assignee: Corning

Describes an array that "overcomes the problems and disadvantages associated with prior art arrays," according to the patent's abstract. The new array comprises a plurality of biological membrane microspots "associated with a surface of a substrate that can be produced, used and stored, not in an aqueous environment, but in an environment exposed to air under ambient or controlled humidities."


US Patent 7,676,328. Method for identifying cell-specific proteins. Inventor: Walter Schubert. Assignee: MPB Meltec Patent Beteiligungsgesellschaft

The method covered includes the determination of cell-specific protein combination patterns of cells of interest; "comparing the protein combination patterns of healthy and pathologically or physiologically modified cells of one cell type or comparing the protein combination patterns of cells of a different cell type affected by the same disease," according to the patent's abstract; removing the "coincident part" of the protein combinations described in the prior step; removing the "non-coincident parts of the second step; determining the cell-specific proteins; and identifying the cell-specific proteins based on molecules and spatial structure.


US Patent 7,674,766. Mass spectrometry-based identification of proteins. Inventor: Samie R. Jaffrey. Assignee: Cornell Research Foundation

Described is a method to C-terminally label proteins in a complex sample, and then identify them by mass spectrometry.


US Patent 7,674,752. Functional protein arrays. Inventors: Mingyue He; Michael John Taussig. Assignee: Discema Limited

Pertains to a method of producing a protein array starting from DNA or mRNA "in which a number of native, functional proteins, domains or peptides are produced in parallel by in vitro synthesis using a cell-free system for transcription and translation," according to the patent's abstract.


US Patent 7,674,593. Preparation method of biotinylated protein and detection method using the same. Inventors: Yaeta Endo; Tatsuya Sawasaki; Yuko Matsubara. Assignee: CellFree Sciences

Covers a detection method that does not require removing free biotin during preparation of a biotinylated protein having a biotin tag.

The Scan

Driving Malaria-Carrying Mosquitoes Down

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Office Space to Lab Space

The New York Times writes that some empty office spaces are transforming into lab spaces.

Prion Pause to Investigate

Science reports that a moratorium on prion research has been imposed at French public research institutions.

Genome Research Papers on Gut Microbe Antibiotic Response, Single-Cell RNA-Seq Clues to Metabolism, More

In Genome Research this week: gut microbial response to antibiotic treatment, approach to gauge metabolic features from single-cell RNA sequencing, and more.