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Recent Patents of Interest in Proteomics: Dec 4, 2009

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US Patent 7,622,306. Using plasma proteomic pattern for diagnosis, classification, prediction of response to therapy and clinical behavior, stratification of therapy, and monitoring disease in hematologic malignancies. Inventors: Maher Albitar; Elihu H. Estey; Hagop M. Kantarjian; Francis J. Giles; Michael J. Keating. Assignee: Board of Regents, University of Texas System

According to the abstract, the invention "demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample." Plasma samples are collected from patients with hematologic malignancies, protein spectra are generated and compared with clinical data, and protein markers are identified. A protein profile is created that can be used to diagnose the hematologic malignancy or to determine the prognosis of the malignancy. "Potentially these specific proteins can be identified and targeted in the therapy of these malignancies," according to the abstract.


US Patent 7,622,273. Method for chemical and enzymatic treatment of post-translationally modified proteins bound to a protein chip. Inventor: Bernard F. Gibbs. Assignee: N/A

A "simple and quick" protocol for chemical treatment, enzymatic or chemical digestion, and identification of proteins or polypeptides on a protein chip such as protein chip arrays is provided. The chemical treatment includes denaturation, reduction, and alkylation. Enzymatic digestion includes deglycosylation, dephosphorylation, and digestion by various proteases. "The methods of the present invention allow complete on-chip treatment, which can be used for rapid protein identification and structural characterization of heavily post-translationally modified proteins," according to the abstract.


US Patent 7,622,261. Method for the diagnosis of cancers by measuring the changes of glycosylation of proteins related to tumorigenesis and metastasis and kit for diagnosis of cancers using the same. Inventors: Jeong Heon Ko; Soo Young Hwang; Hosung Sohn; Sejeong Oh; Jeong Hwa Lee; Sang Chul Lee; Jong-Shin Yoo; Dae-Sil Lee. Assignee: Korea Research Institute of Bioscience and Biotechnology

Pertains to a method for the diagnosis of cancers by measuring proteins associated with tumorigenesis and metastatis, and a diagnostic kit. In particular, the method and the kit relates to diagnosing cancers by measuring changes in the glycosylation of proteins.


US Patent 7,618,806. Methods and apparatus for mass spectral analysis of peptides and proteins. Inventors: James P. Reilly; Matthew S. Thompson. Assignee: Indiana University Research and Technology

Pertains to an apparatus, device, and methods for fragmenting high molecular weight ions such as peptides and proteins. Ions are treated with predetermined wavelengths of light. In one embodiment, vacuum ultraviolet radiation is described as a source of predetermined wavelengths of laser light. Described also is a device in which a sample enters through an inlet and is irradiated with a first source of light.


US Patent 7,618,788. Proteome epitope tags and methods of use thereof in protein modification analysis. Inventors: Frank D. Lee; Xun Meng; Noubar B. Afeyan. Assignee: Millipore

Pertains to methods for detecting the presence of proteins, including post-translation modifications, in a sample. One or more capture agents are used that "recognize and interact with recognition sequences uniquely characteristic of a protein or a set of proteins in the sample," according to the abstract. Arrays comprising the capture agents are also provided.


US Patent 7,615,368. Microarrays of polypeptides. Inventors: Patrick Brown; Tidhar Shalon. Assignee: The Board of Trustees of the Leland Stanford Junior University

Microarrays of polypeptides are described. The microarrays are used for the multiplexed detection and quantitation of ligands in a miniaturized format. "The substrate is used for detecting binding of ligands to a plurality of polypeptides for screening and diagnostic purposes," according to the abstract.

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US Patent 7,615,354. Electrophoretic separation of compounds. Inventors: Michel D. Faupel; Hubert H. Girault; Frederic Reymond; Alexandra Ros; Joel Stephane Rossier. Assignee: Ecole Polytechnique Federale de Lausanne

Pertains to a device, method, and kit for "the electrophoretic separation and purification of charged and neutral compounds in an analyte solution," according to the abstract. A method for collecting separated compounds, "preferably in ampholyte-free or buffer-free solution and …means for recycling the separated fractions," is provided.


US Patent 7,612,019. Polypeptide display libraries and methods of making and using thereof. Inventors: Patrick Daugherty; Paul H. Bessette; Jeffrey Rice. Assignee: The Regents of the University of California

Pertains to expression vectors, which display a passenger polypeptide on the outer surface of a biological entity. The displayed passenger polypeptide is capable of interacting or binding with a given ligand. Methods of making and using the expression vectors are also described, as are methods of making and using N- or C-terminal fusion expression vectors.


US Patent 7,611,834. Methods and devices for protein assays. Inventors: Swapnil Chhabra; Jose M. Cintron; Renee Shediac. Assignee: Sandia

The protein assays are based on Edman degradation in microfluidic channels. The cleaved amino acid residues may be immobilized in an array format and identified by detectable labels.


US Patent 7,608,819. Mass spectrometer. Inventors: Takashi Baba; Yuichiro Hashimoto. Assignee: Hitachi High-Technologies

Provided is a mass spec capable of high-efficiency and high-throughput electron-capture dissociation. "An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used," according to the abstract.


US Patent 7,608,406. Diagnostic markers of stroke and cerebral injury and methods of use thereof. Inventors: Gunars F. Valkirs; Jeffrey Dahlen; Howard J. Kirchick; Kenneth Buechler. Assignee: Biosite

Disclosed are a variety of markers for assembling a panel for use in diagnosing and evaluating stroke and transient ischemic attacks. Methods are also provided for "rapid, sensitive, and specific" assays.

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