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Recent Patents of Interest in Proteomics: Nov 6, 2009


US Patent 7,605,003. Use of biomarkers for detecting ovarian cancer. Inventors: Daniel Chan; Zhen Zhang; Eric Fung; Xiao-Ying Meng. Assignees: Johns Hopkins University; Vermillion

Pertains to a method of qualifiying ovarian cancer status in a patient. The method comprises measuring at least one biomarker in a sample from the patient, then correlating the measurement with ovarian cancer status. The invention also relates to kits for qualifying ovarian cancer status in a patient.

US Patent 7,604,982. High-throughput screening method for integrin antagonist and new peptide screened therefrom. Inventors: Moon-Hi Han; In-Cheol Kang; Yoon-Suk Lee; Soo-Ik Chang. Assignee: Proteogen

Pertains to a method for screening antagonistic material of integrin using protein chips and "useful peptides screened thereby," according to the abstract. The protein chip is a "unique substrate coated with new material, calixarene derivative, which can keep uniform and high activities of proteins."

US Patent 7,604,980. Protein expression system. Inventors: Sanjeev Galande; Prabhat Purbey; Peter Jayakumar; Milind Patole. Assignee: National Centre for Cell Science

Pertains to the downstream processing of proteins and novel expression cassettes "having unique cleavage sites for efficient removal of purification tags," according to the abstract. Provided are expression systems and methods for purifying and isolating proteins.

US Patent 7,604,956. Supersensitive immunoassays. Inventor: Andrzej Drukier. Assignee: BioTraces

Pertains to an assay that has 10-fold improved sensitivity over other immunoassays such as ELISA. Three main implementations are described: immunoassay using multiphoton-detection; super-ELISA; and reverse geometry immunoassay "including specific panel biomarker relationships for the early detection and recognition patterns of breast and prostate cancers," according to the abstract.

US Patent 7,603,240. Peptide identification. Inventors: Brian Halligan; Edward Dratz. Assignee: MCW Research Foundation

Provided is a method for identifying peptides, as well as related peptide databases, method of generating the databases, computer-useable media, and computer program products. The method involves using qualitative amino acid compositions or partial qualitative amino acid composition of a query peptide obtained by mass spectrometry "to correlate the query peptide to one or more peptides with defined amino acid sequences in a peptide database generated according to the present invention," according to the abstract.

US Patent 7,598,486. Sample plate for glycoprotein analysis by MALDI mass spectrometry and preparation of the same. Inventors: Yangsun Kim; Jeong Heon Lee; Mi Young Ha; Ho Chul Jung; Hyoung Soon Park. Assignee: Yangsun Kim

The sample plate described in the invention has a stable glycol-affinity layer of a carboxyalkyl boronic acid or carboxyaryl boronic acid. A method of preparing the sample plate is also described. The plate "shows excellent selectivity" for glycoproteins and is easily and inexpensively made, according to the abstract.

US Patent 7,598,033. Method and devices for running reactions on a target place for MALDI mass spectrometry. Inventors: Scott Diamond; Dhaval Gosalia. Assignee: University of Pennsylvania

Pertains to a peptide or protein microassay method and apparatus "in which a wide variety of chromogenic, or fluorogenic peptide, or protein substrates of interest are individually suspended or dissolved in a hydrophilic carrier, with aliquots of each substrate being deposited in an array or microarray of reaction loci, or 'dots,'" according to the abstract. Each dot provides an individual reaction vessel containing the peptide or protein of interest. For assay purposes, a biological sample may be applied to the array or microarray of dots by a variety of focused sample application techniques. In additional aspects, the invention provides methods of transferring samples from an electrophoretic gel to a target plate for MALDI-MS analysis.

The Scan

Dropped Charges

The US Justice Department has dropped visa fraud charges against five Chinese researchers, according to the Wall Street Journal.

More Kids

The Associated Press says Moderna is expanding its SARS-CoV-2 vaccine study to included additional children and may include even younger children.

PNAS Papers on Rat Clues to Human Migration, Thyroid Cancer, PolyG-DS

In PNAS this week: ancient rat genome analysis gives hints to human migrations, WDR77 gene mutations in thyroid cancer, and more.

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.