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Recent Patents of Interest in Proteomics: Jul 30, 2009

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US Patent 7,563,598. Detection of truncation mutations by mass spectrometery. Inventors: Alex Garvin, Sadanand Gite; Vladislav Bergo; Kenneth Rothschild. Assignee: Ambergen

Pertains to the detection and analysis of nascent proteins by mass spectrometry, in particular, truncated proteins translated within cellular or cell-free translations systems. "N-terminal and C-terminal epitopes introduced into these nascent proteins permit rapid and efficient isolation, as well as mass difference," according to the abstract.


US Patent 7,563,584. Methods and compositions for detecting the activation state of multiple proteins in single cells. Inventors: Omar Perez; Garry P. Nolan. Assignee: Board of Trustees of the Leland Stanford Junior University

Covers methods and compositions for the simultaneous detection of the activation state of a plurality of proteins in single cells using flow cytometry. Provided further are methods and compositions of screening for bioactive agents "capable of coordinately modulating the activity of a plurality of proteins in single cells," according to the abstract. The methods and compositions can be used to determine the protein activation profile of a cell for disease prediction or diagnosis, and for monitoring treatments.


US Patent 7,560,535. Glycoprotein synthesis. Inventors: Peter Schultz; Lei Wang; Zhiwen Zhang. Assignee: The Scripps Research Institute

Covers methods for making glycoproteins, in vivo and in vitro. One method calls for incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves involving an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by either method can be further modified with additional sugars.


US Patent 7,560,258. Glass-immobilized, protein-acrylamide copolymer and method of making thereof. Inventors: Shawn B. Brueggemeier; Stephen J. Kron; Sean P. Palecek. Assignees: Wisconsin Alumni Research Foundation; University of Chicago.

Pertains to a method of using polyacrylamides to make surface-bound peptide and protein arrays, and a method of using the arrays to detect proteins and measure their concentration, binding affinity, and kinetics. Peptides, proteins, fusion proteins, and protein complexes are labeled with an acrylic moiety, then attached to acrylic-functionalized glass surfaces through a copolymerization with acrylic monomer.


US Patent 7,560,030. Method for separation and enrichment of phosphopeptides. Inventors: Hanfa Zou; Houjiang Zhou; Mingliang Ye; Shun Feng. Assignee: Dalian Institute of Chemical Physics, Chinese Academy of Sciences

Covers a method of phosphopeptide isolation and in particular a highly selective and specific method of phosphopeptide enrichment. The method is based on the "strong" interaction between zirconium phosphonate and phosphopeptides, and shows "high specificity" for phosphopeptides and can be used to purify and enrich low-abundance phosphopeptides.


US Patent 7,557,342. Electrospray systems and methods. Andrei G. Federov; F. Levent Degertekin. Assignee: Georgia Tech Research Corp.

Covers electrospray systems, electrospray structures, removable electrospray structures, methods of operating electrospray systems, and methods of fabricating electrospray systems.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.