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Recent Patents of Interest in Proteomics: Jun 11, 2009

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US Patent 7,541,578. Microfluidic device and manufacturing method thereof. Inventor: Kuo-Yao Weng. Assignee: Industrial Technology Research Institute

Pertains to a method for manufacturing a microfluidic device. According to the abstract, a substrate having at least one device thereon is provided "wherein the device includes at least one channel." A region beside the channel is heated and the substrate is pulled "to neck the region such that at least one capillary connecting with the channel is formed." The invention also includes a microfluidic device including a substrate and at least one capillary.


US Patent 7,541,576. Method of multiplexed analysis using ion mobility spectrometer. Inventors: Mikhail Belov; Richard Smith. Assignee: Battelle Memorial Institute

The method involves generating a pseudo random sequence of a modulation bins, organizing the bins as a series of submodulation bins, releasing the analytes being analyzed in a series of analyte packets into a mass spec, detecting the analytes, and "characterizing the sample using the plurality of analyte signal subvectors," according to the abstract.


US Patent 7,541,197. Planar optical waveguide-based sandwich assay sensors and processes for the detection of biological targets including protein markers, pathogens, and cellular debris. Inventors: Jennifer Martinez; Basil Swanson; Karen Grace; Wynne Grace; Andrew Shreve. Assignee: Los Alamos National Security

Pertains to an assay element that includes recognition ligands bound to a film on a single mode planar optical waveguide, the film from the group of a membrane, a polymerized bilayer membrane, and a self-assembled monolayer containing polyethylene glycol or polypropylene glycol groups therein. An assay process for the detection of a biological target is also described.


US Patent 7,541,003. Latex-based adsorbent chip. Inventors: Christopher Pohl; Steven Papanu. Assignee: Bio-Rad Laboratories

The invention provides an adsorbent chip, which includes a substrate, an intermediate layer of linker arms, and an adsorbent film attached to the linker arms. Also provided is a method of making the chips and methods for using the chips to perform assays.


US Patent 7,538,321. Methods of identifying substances using mass spectrometry. Inventors: Masako Ishimaru; Atsumu Hirabayashi; Kinya Kobayashi; Kisaburo Deguchi. Assignee: Hitachi High-Technologies

According to the abstract, the invention aims to provide a mass spectrometry system that would more efficiently obtain information on substance structures, which in turn would shorten the amount of time needed for measurement and substance identification and improving identification accuracy. The system comprises a process of mass analyzing an ionized analyte; a first fragmentation process; a method to analyze a plurality of the ions generated in the first fragmentation process; "a process of determining fragment ion combination capable of reconstructing the first ion using" data from mass spectrometry; a second fragmentation process; and a method to analyze the fragment ions generated in the second fragmentation.

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US Patent 7,537,938. Biomarker detection in circulating cells. Inventors: Hrair Kirakossian; Thomas Klopack; Sharat Singh. Assignee: Monogram Biosciences

Pertains to a method for detecting biomarkers in rare circulating cells by forming "an enriched population of cells immunomagnetically followed by biomarker detection using binding compounds having releasable molecular tags," according to the abstract.


US Patent 7,537,694. Method and device for multidimensional liquid chromatography. Inventors: Masaki Watanabe; Shinya Ito; Katsuhiro Kanda. Assignee: Hitachi High-Technologies

In the liquid chromatograph, an injector would direct an electrolytic solution toward a specimen in a first separation column to transfer components of the specimen from the first separation column toward one of first and second trap columns. Another eluting liquid then flows through the other of the first and second trap columns toward a second separation column.


US Patent 7,534,622. Electron transfer dissociation for biopolymer sequence mass spectrometric analysis. Inventors: Donald Hunt; Joshua Coon; John Syka; Jarrod Marto. Assignee: University of Virginia Patent Foundation

Describes a method for fragmenting ions in a mass spectrometer by electron transfer dissociation, and doing a sequence analysis of peptides and proteins by mass spectrometry. "In the case of peptides, the invention promotes fragmentation along the peptide backbone and makes it possible to deduce the amino acid sequence of the sample, including modified amino acid residues, through the use of an RF field device," according to the abstract.


US Patent 7,534,578. Self-referencing biodetection method and patterned bioassays. Inventors: Cheryl Baird; Brian Cunningham. Assignee: SRU Biosystems

Pertains to compositions and methods for detecting biomolecular interactions. The detection can be done label-free and in a high-throughput manner. The invention also relates to "self-referencing colorimetric resonant optical biosensors and optical devices," according to the abstract.


US Patent 7,534,563. Methods for producing ligand assays. Inventor: John Hargreaves. Assignee: Agilent Technologies

Included are methods for producing ligand substrates and arrays, including peptide and nucleic acid arrays, as well as the arrays produced thereby, and methods for use of the arrays. "A substrate having a surface displaying photocleavable functional groups upon irradiation is first provided, where the photocleavable groups are then cleaved to produce a surface that displays desired functional groups," according to the abstract. The resulting substrates are contacted with ligands or monomeric precursors, "resulting in covalent attachment of the contacted ligands to the surface."

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