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Recent Patents of Interest in Proteomics: May 7, 2009


US Patent 7,528,366. Method and apparatus for multiplexing plural ion beams to a mass spectrometer. Inventors: James G Boyle; Robert A Valley. Assignee: Analytica of Branford

Provided are at least two ion sources with means of transporting the ions from the ion sources to separate 2D ion traps. Each ion trap is for storage and transmission of the ions and operates between the ion sources and the mass analyzer. Each also has a set of equally spaced, parallel multipole rods and entrance and exit section for ions to enter and exit the trap. For each ion trap, the entrance section is located in an area where background gas pressure is at viscous flow, and the pressure at the exit section "drops to molecular flow pressure regimes without a break in the structure of the ion trap," according to the abstract. Each trap alternately stores and transmits ions "by way of a fast voltage switch applied to the ion trap exit lens," the inventors said in the abstract.

US Patent 7,525,105. Laser desorption-electrospray ion source for mass spectrometers. Inventor: Viatcheslav V Kovtoun. Assignee: Thermo Finnigan [now Thermo Fisher Scientific]

Describes an ion source to form multiply-charged analyte ions from a solid sample. According to the abstract, a beam of pulsed radiation is directed onto a portion of the sample "to desorb analyte molecules." A retaining structure holding a solvent is situated next to the sample. "Desorbed analyte molecules contact a free surface of the solvent and pass into solution," the inventor said in the abstract. "The solution is then conveyed through an outlet passageway to an electrospray apparatus, which introduces a spray of charged solvent droplets into an ionization chamber."

US Patent 7,524,925. Protein interaction reporter agents and methods for using same. Inventors: James E Bruce; Xiaoting Tang; Gerhard Munske. Assignee: Washington State University

In certain aspects, novel protein interaction reporter compounds are provided. The compounds comprise at least two protein reactive moieties, "each linked to a reporter moiety … by a covalent labile bond that is differentially cleavable with respect to peptide bonds … wherein the reporter moiety is operatively releasable from the PIR agent upon cleavage of the labile bonds, the released reporter moiety having a characteristic identifying property or label," according to the abstract. Particular PIRs comprise a mass reporter moiety, further comprising an affinity group linked to the PIR. Additional aspects provide methods to characterize intermolecular or intramolecular protein interactions using at least one PIR compound.

US Patent. 7,523,026. Proteome analysis method and proteome analysis system. Inventors: Kenichiro Tsuda; Jiro Shimada; Minoru Asogawa; Kenichi Kamijyo; Toshimasa Yamazaki. Assignee: NEC

The analysis method includes use of an MS/MS to calculate bond dissociation energy by using molecular simulation, using the bond dissociation energy to obtain prediction information, including cleavage patter of a peptide and/or peak positions in a mass spec, and/or the intensity ratio of the mass spectrum. The prediction experiment information is used to identify proteins.

US Patent 7,522,271. Microarray detector and synthesizer. Inventor: Perry Sandstrom. Assignee: Able Signal

Pertains to novel systems, devices, and methods comprising spatial light modulators to read and make microarrays.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.