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Recent Patents of Interest in Proteomics: Mar 26, 2009


US Patent 7,507,953. Obtaining tandem mass spectrometry data for multiple parent ions in an ion population. Inventors: Alexander Alekseevich Makarov; John Edward Philip Syka. Assignee: Thermo Finnigan [now called Thermo Fisher Scientific]

In particular, the invention pertains to MS/MS using a linear ion trap and a TOF detector to collect mass spectra to form a MS/MS experiment. "The accepted standard is to store and mass analyze precursor ions in the ion trap before ejecting the ions axially to a collision cell for fragmentation before mass analysis of the fragments in the time of flight detector," according to the abstract. The invention uses orthogonal ejection of ions with a narrow range of m/z values "to produce a ribbon beam of ions that are injected into the collision cell."

US Patent 7,504,621. Method and system for mass analysis of samples. Inventor: Igor Chernushevich; Assignee: MDS

Pertains to a method and system for analyzing a sample. The system includes an ion source and a deflector for producing a plurality of ion beams. Each of the beams is detected in distinct detection regions. A detection system uses the information obtained from the detection region to analyze the sample.

US Patent 7,504,364. Methods of making arrays and artificial receptors. Inventor: Robert Carlson. Assignee: Receptors

Pertains to artificial receptors and arrays/microarrays of artificial receptors or candidate artificial receptors. Each member of the arrays includes multiple building-block compounds, typically immobilized in a spot on a support. The invention includes the building blocks, combinations of building blocks, arrays of building blocks, and receptors constructed of these building blocks "together with a support," according to the abstract. It also includes methods for making and using the arrays and receptors.

US Patent 7,501,286. Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry. Inventors: Steven Gygi; Scott Anthony Gerber. Assignee: President and Fellows of Harvard College

Provided are reagents, kits, and methods for detecting and/or quantifying proteins in a complex mixture. The methods can be used in high-throughput assays to profile cellular proteomes. A peptide internal standard labeled with a stable isotope and corresponding amino acid sequence to the amino acid sequence of a subsequence of target polypeptide is provided in one aspect. In another aspect, the peptide internal standard is labeled at modified amino acid residue and used to determine the presence of, and/or to quantitate the amount of a specific modified protein form.

US Patent 7,499,807. Methods for recalibration of mass spectrometry data. Inventors: Aleksey Tolmachev; Richard D Smith. Assignee: Battelle Memorial Institute

The methods for recalibrating mass spectrometry described provide improvement in both mass accuracy and precision "by adjusting for experimental variance in parameters that have a substantial impact on mass measurement accuracy," according to the abstract.

US Patent 7,498,568. Real-time analysis of mass spectrometry data for identifying peptidic data of interest. Inventors: Gregor T Overney; Joseph Charles Roark. Assignee: Agilent Technologies

Described is a mass spectrometry system comprising a mass spectrometer and a controller connected to the mass spectrometer. For some implementations, the controller allows automated, data-dependent acquisition of MS data "to improve the efficiency at which peptidic data of interest can be acquired," according to the abstract.

US Patent 7,497,937. Microfabricated chip and method of use. Inventors: Edward S Yeung; Ho-Ming Pang; Futian Han. Assignee: Combisep

Pertains to a multiplexed, absorbance-based microfabricated chip electrophoresis system, microfabricated chip, and method for the detection and identification of protein species. The chip electrophoresis system can analyze multiple samples at once, according to the abstract. "In use, the sample is placed into a sample chamber, a barrier is established around the sample chamber, the sample is isoelectrically focused within the sample chamber, the barrier is then removed, and the sample separated in the first array of channels by molecular weight," according to the abstract.