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Recent Patents of Interest in Proteomics: Feb 26, 2009

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US Patent 7,495,231. MALDI sample plate imaging workstation. Inventors: Jean-Luc Truche; Gregor T Overney; William D Fisher; Richard P Tella. Assignee: Agilent Technologies

The patent covers an apparatus "for producing an image of a global surface of an ion source sample plate that is exterior to an ion source," according to the abstract. Generally, the apparatus contains a sample plate for an ion source, an imaging device, and an illumination device configured to produce a light beam that contacts the sample plate, defining a grazing angle between the light beam and the sample plate surface.


US Patent 7,494,788. Entropic bristle domain sequences and their use in recombinant protein production. Inventors: Keith Dunker; Vladimar N Uversky; Marc S Cortese; James Mueller. Assignee: Molecular Kinetics

Provided are compositions for recombinant protein production, particularly for fusion polypeptides, polynucleotides encoding fusion polypeptides, expression vectors, kits, and related methods for recombinant protein production.


US Patent 7,493,225. Method for calibrating mass spectrometry (MS) and other instrument systems and for processing MS and other data. Inventors Youngdong Wang; Ming Gu. Assignee: Cerno Boscience.

The IP covers a method for obtaining at least one calibration filter for an MS system. Measured isotope peak cluster data in a mass spectral range is obtained for a given calibration standard. Relative isotope abundances and actual mass locations of isotopes corresponding thereto are calculated for the given calibration standard. "Mass spectral target peak shape functions centered within respective mass spectral ranges are specified," according to the abstract. "Convolution operations are performed between the calculated relative isotope abundances and the mass spectral target peak shape functions to form calculated isotope peak cluster data. A deconvolution operation is performed between the measured isotope peak cluster data and the calculated isotope peak cluster data after the convolution operations to obtain the at least one calibration filter."


US Patent 7,491,304. Carrierless electrophoresis process and electrophoresis device for carrying out this process. Inventor: Gerhard Weber. Assignee: Becton Dickinson

The patent protects a free-flow electrophoresis method for the separation of sample substances into their analytes. The first step of the method calls for the crude fractionation of the sample substance, It also calls for at least one other step in which the crudely fractionated sample substance is finely fractionated.


US Patent 7,488,603. Method and device for extracting an analyte. Inventors: Douglas T Gierde; Christopher P Hanna. Assignee: PhyNexus

Provided are extraction columns for the purification of an analyte, such as a protein or peptide, from a sample solution. Methods for making and using such columns are also described.


US Patent 7,485,855. On-probe sample cleanup system and method for MALDI analysis. Inventors: Appavu K Sundaram; Nelli I. Taranenko; Vladimir M. Doroschenko. Assignee: Science and Engineering Services

Described is a system and method for the cleanup of biological samples from contaminants before analysis by spectroscopy. The system includes a support to hold a sample, including a liquid having at least one group of biological molecules with a surface of the support "binding the molecules at a surface tension angle to the liquid of less than 180 degrees," according to the abstract. It also includes an evaporator configured to evaporate liquid from the support.


US Patent 7,485,853. Mass spectrometric mixture analysis. Inventors: Markus Lubeck; Christian Gebhardt; Thorsten Ledertheil. Assignee: Bruker Daltonik

The mass-spectrometric analysis allows for the determination of both simple mass spectra of substances and more detailed information about structures and other characteristics of the substances. The substance mixture is termporally separated in a separation device, the eluating flow of substances are split into at least two partial flows, and the substances in the different partial flow are measured by mass spectrometry.


US Patent 7,485,852. Mass analysis method and mass analysis apparatus. Inventors: Hiromich Yamashita; Akihio Takeda; Tomoyuki Kurosawa; Kinya Kobayashi. Assignee: Hitachi High-Technologies

The patent protects a mass-analysis method that can identify proteins or peptides with "high speed and high sensitivity," according to the abstract. A mass spectrum is obtained from a standard sample of a healthy person. An ion is selected from the mass spectrum to be a precursor ion, and a mass spectrum of the precursor ion is obtained. A mass spectrum is obtained from a sample of interest to be measured of patient, and an ion other than the precursor ion of the standard sample is selected from the mass spectrum as a precursor ion. A mass spectrum of the precursor ion is obtained. Identifications of peptide or protein specific to the standard sample and the sample to be measured, which are common to both are made. Based on the result, a comparative analysis of the peptide/protein of the sample to be measured is done.

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