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Recent Patents of Interest in Proteomics : Oct 2, 2008

US Patent 7,429,466. Methods and arrays for detection biological molecules. Inventors: Yingjian Wang. Assignee: Hypromatrix
The methods described comprise providing a first support immobilized with at least one reagent; providing a second support immobilized with at least one ligand; contacting the reagents immobilized to the first support with the ligands immobilized in the second support “whereby one or more of the reagents bind to one or more of the ligands,” according to the abstract; and separating the first from the second support “so that one or more of the bound reagents remain bound to one or more ligands on the second support after separation.”

US Patent 7,427,656. Peptide tags for the expression and purification for bioactive peptides. Inventors: Linda Decarolis; Stephen Fahnestock; Hong Wang. Assignee: E.I. du Pont de Nemours
Described are peptide tags for the generation of insoluble fusion peptides. The peptides comprise at least one inclusion body tag operably linked to a peptide of interest. “Expression of the fusion peptide in a host cell results in a product that is insoluble and contained within inclusion bodies in the cell and/or cell lysate,” according to the abstract. The inclusion bodies can then be purified and the protein of interest can be isolated after cleaving from the inclusion body tag.

US Patent 7,425,700. Systems and methods for discovery and analysis of markers. Inventors: John Stults; Alfred Greenquist; Alexander Sassi. Assignee: N/A
Described are systems and methods for identifying new markers, diagnosing patients “with a biological state of interest,” and commercializing such diagnostics, according to the abstract. The systems and methods described have greater sensitivity, specificity, and are more cost effective than current comparable methods, the inventors say.

US Patent 7,425,451. Triazine derivatives as universal peptide isotope tag reagents (U-PIT). Inventors: Karla Robotti; James Apffel. Assignee: Agilent Technologies
Invention pertains to compounds, compositions, and methods for sequencing proteins and peptides, as well as methods of identifying proteins and peptides in a mixture. Compounds of formula A-B-C are used to label the peptides at the N-terminus or the C-terminus, where A is a nucleophilic reactive group, B is a detectable moiety “capable of being isotopically labeled,” and C is a charge replacement group, the inventors said in the abstract. Mass spectrometry is used to analyze the tagged peptides.

US Patent 7,423,132. Method for the enrichment and characterization of phosphorylated peptides or proteins. Inventors: Jetze Tepe; Thomas Pinnavaia. Assignee: Board of Trustees of Michigan State University
Invention pertains to a method for separating and assaying phosphorylated peptides or proteins from complex mixtures of peptides and proteins. The method uses a diazo moiety linked by an organic group to a substrate. The invention also describes kits for performing the assays.

US Patent 7,423, 122. N-terminal and C-terminal markers in nascent proteins. Inventors: Kenneth Rothschild; Sadanand Gite; Jerzy Olejnik. Assignee: N/A
Described are non-radioactive markers for detecting and analyzing nascent proteins translated within cellular or cell-free translation systems. Nascent proteins containing these markers can be “rapidly and efficiently detected isolated, and analyzed without the handling and disposal problems associated with radioactive reagents,” according to the abstract. Described are methods for incorporating N-terminal, C-terminal, and affinity markers into a nascent protein.

US Patent 7,422, 891. Label-free high-throughput optical technique for detecting biomolecular interactions. Inventor: Brian Cunningham. Assignee: SRU Biosystems
Invention pertains to methods and compositions for detecting biomolecular interactions in which labels are not required. Methods can be done in high throughput. The invention also provides optical devices useful as narrow band filters.

US Patent 7,422,865. Method of identifying peptides in a proteomic sample. Inventors: Steven Fischer. Assignee: Agilent Technologies
Invention pertains to a new method for reducing the complexity of a proteomic sample and identifying the proteins in the sample. The invention provides methods for identifying proteins by characterizing a single N- or C-terminal peptide per protein. In another aspect, the invention provides a method for quantitatively determining differential protein expression and/or modification in different samples. Kits useful for performing a method in accordance to the invention are also described.

US Patent 7,422,855. Multiplexing assays for analyte detection. Inventors: Joseph DiCesare; Assignee: PerkinElmer LAS
Described are high-density multiplexing assays for proteins, nucleic acids, and other molecules. The assays are based on detection by mass spectrometry and use a solid-state support format, whereby the bead carries “both a coding molecule to track the sample or analyte and the molecule(s) necessary to perform an affinity-based assay,” according to the abstract. After completion of all necessary reactions, all of the components are dissociated for mass spec analysis. Methods for detecting the assays include different types of mass specs with different sampling systems.

The Scan

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.

Clinical Genomic Lab Survey Looks at Workforce Needs

Investigators use a survey approach in Genetics in Medicine Open to assess technologist applications, retention, and workforce gaps at molecular genetics and clinical cytogenetics labs in the US.

Study Considers Gene Regulatory Features Available by Sequence-Based Modeling

Investigators in Genome Biology set sequence-based models against observational and perturbation assay data, finding distal enhancer models lag behind promoter predictions.

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.