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Recent Patents of Interest in Proteomics : Oct 30, 2008

US Patent 7,442,773. Universal peptide-binding scaffolds and protein chips. Inventors: Huimin Zhao; Olga Esteban. Assignee: The Board of Trustees of the University of Illinois
The scaffold is used to bind a target, which can be a peptide or peptides of interest , or peptides representing the entire proteome. The target can be protein fragments prepared by enzymatic digestion of the whole proteome or N- or C-terminal short sequences exposed by chemical denaturation of the entire proteome.

US Patent 7,442,556. Microfluidic-based electrospray source for analytical devices with a rotary fluid flow channel for sample preparation. Inventors: Ian Manger; Cunsheng Hao; Marc Unger. Assignee: Fluidigm
Provided are microfluidic devices and methods for using the devices. The device comprises a first elastic layer, a fluid flow channel within the elastic layer, and a means for providing a fluid sample from the fluid flow channel to an analytical device. An analytical apparatus comprising such a microfluidic device and an analytical device is also provided.

US Patent 7,439,337. Three-phase partitioning method for purifying a protein. Inventor: William Ward. Assignee: Rutgers, the State University of New Jersey
Invention is a kit and method for purifying a protein of interest. The kit consists of a solution of ammonium sulfate containing an indicator dye and a solution of tertiary butanol and isopropanol at a ratio of 3:7. The protein of interest is mixed with the solutions. The mixture is then separated to obtain a layer containing the protein of interest. The layer containing the protein is collected.

US Patent 7,438,856. Microfluidic devices and methods. Inventors: Paul Jedrzejewski, Steffen Nock; Peter Wagner; Pierre Indermuhle; Frank Zaugg. Assignee: Zyomyx
Invention pertains to microfluidic devices. In one embodiment, “a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening,” according to the abstract. “The transfer-separation channel terminates in a discharge aperture.”

US Patent 7,435,951. Ion source sample plate illumination system. Inventors: Jean-Luc Truche; Gregor Overney; William Fisher; Richard Tella. Assignee: Agilent Technologies
Provided is a mass spectrometry system ion source containing a sample plate and an illumination device configured to produce a light beam that contacts the sample plate surface “to define a grazing angle between the light beam and the sample plate surface,” according to the abstract. Methods and MS systems employing the ion source are provided.

US Patent 7,435,385. Label-free high-throughput optical technique for detecting biomolecular interactions. Inventors: Bo Lin; Peter Li. Assignee: SRU Biosystems
Provided are methods and compositions for the detection of biomolecular interactions. Labels are not required and the methods can be done in a high-throughput manner, according to the abstract. Provided also are optical devices useful as narrow band filters.

US Patent 7,429,727. Method, apparatus, and program product for quickly selecting complex molecules from a database of molecules. Inventor: Marshall Bern. Assignee: Palo Alto Research Center
The invention relates to the analysis of dissociation spectrum data including spectral peaks representing fragments of a parent ion. The parent ion includes molecular subunits connected at cleavage sites. The technology described accesses the dissociation spectrum data, determining a reference mass of one of the fragments “where at least one of the molecular subunits in the fragment is known,” according to the abstract. The invention selects a candidate parent ion description from a database of molecule descriptions “where a computed ion mass of the candidate parent ion description matches the reference mass and scores the candidate parent ion description,” the inventor said in the abstract.

The Scan

Study Reveals New Details About Genetics of Major Cause of Female Infertility

Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.

Circulating Tumor DNA Shows Potential as Biomarker in Rare Childhood Cancer

A study in the Journal of Clinical Oncology has found that circulating tumor DNA levels in rhabdomyosarcoma may serve as a biomarker for prognosis.

Study Recommends Cancer Screening for Dogs Beginning Age Seven, Depending on Breed

PetDx researchers report in PLOS One that annual cancer screening for dogs should begin by age seven.

White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds

A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.