US Patent 7,442,773. Universal peptide-binding scaffolds and protein chips. Inventors: Huimin Zhao; Olga Esteban. Assignee: The Board of Trustees of the University of Illinois
The scaffold is used to bind a target, which can be a peptide or peptides of interest , or peptides representing the entire proteome. The target can be protein fragments prepared by enzymatic digestion of the whole proteome or N- or C-terminal short sequences exposed by chemical denaturation of the entire proteome.