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Recent Patents of Interest in Proteomics: Oct 7, 2005

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US Patent No. 6,949,739. Ionization at atmospheric pressure for mass spectrometric analyses. Inventor: Jochen Franzen. Assignee: Bruker Daltonik.

This invention relates to the feeding of analyte ions, generated at atmospheric pressure, efficiently into the mass spectrometer. The invention provides a lengthy ion mobility drift tube with a focusing electric field inside to guide the ions from an ionization cloud generated at atmospheric pressure towards the entrance of the mass spectrometer. The invention also dries droplets which might occur in the ionization cloud using a hot drying gas that flows through the ion mobility drift tube towards the ionization cloud.


US Patent No. 6,943,346. Method and apparatus for mass spectrometry analysis of aerosol particles at atmospheric pressure. Inventors: Phillip Tan, Vladimir Doroshenko. Assignee: Science & Engineering Services.

This invention provides an apparatus and method for generating ions from an aerosol and transferring the ions into a mass analyzer. An aerosol beam is generated and directed to a spatial volume outside the mass analyzer. Particles in the aerosol beam are ionized, and the ions are collected in the mass analyzer.


US Patent No. 6,950,754. Apparatus and method for automated protein design. Inventors: Stephen Mayo, Bassil Dahiyat, Benjamin Gordon, Arthur Street, Yaoying Su. Assignee: The California Institute of Technology.

This invention provides an apparatus and method for quantitative protein design and optimization. More specifically, the invention involves a computer program that receives a protein backbone structure with variable residue positions, establishes a group of potential rotamers for each of the variable residue positions, and analyzes the interaction of each of the rotamers with all or part of the remainder of the protein backbone structure to generate a set of optimized protein sequences.


US Patent No. 6,949,565. Protein kinase inhibitors. Inventors: Nurit Livnah, Alexander Levitzki, Hadas Reuveni. Assignee: Develogen Israel, Yissum Research Development Co. of the Hebrew University of Jerusalem.

This invention relates to isoquinoline derivatives, pharmaceutical compositions containing these derivatives, and their use as inhibitors of protein kinases.


US Patent No. 6,946,296. Methods and compositions for polypeptide engineering. Inventors: Phillip Patten, Willem Stemmer. Assignee: Maxygen.

Methods are provided for the evolution of proteins of industrial and pharmaceutical interest. Ways of effecting recombination and selection are included. Compositions produced by these methods are also disclosed.


US Patent No. 6,931,325. Three dimensional protein mapping. Inventors: Daniel Wall, David Lubman, Timothy Barder. Assignee: Regents of the University of Michigan.

This invention relates to multi-phase protein separation methods capable of resolving and characterizing large numbers of cellular proteins. Methods for efficiently facilitating the transfer of protein samples between separation phases are included. In particular, the invention provides systems and methods for the generation of multi-dimensional protein maps, which can result in the improved analysis of samples containing large numbers of proteins.


US Patent 6,949,743. High-Q pulsed fragmentation in ion traps. Inventor: Jae Schwartz. Assignee: Thermo Finnigan.

Rapid and efficient fragmentation of ions in an ion trap for MS/MS analysis is achieved by a pulsed fragmentation technique. Ions of interest are placed at an elevated value of Q and subjected to a relatively high amplitude, short-duration resonance excitation pulse which causes the ions to undergo collision-induced fragmentation. The Q value of the ions of interest is then reduced before significant numbers of ion fragments are expelled from the ion trap, thereby decreasing the low-mass cutoff and allowing retention and subsequent measurement of lower-mass ion fragments.


US Patent No. 6,949,357. Reagents and methods useful for detecting diseases of the urinary tract. Inventors: Patricia Billing-Medel, Maurice Cohen, Tracey Colpitts, Paula Friedman, Julian Gordon, Edward Granados, Steven Hodges, Michael Klass, Jon Kratochvil, Lisa Roberts-Rapp, John Russell, Stephen Stroupe, Hong Yu. Assignee: Abbott Laboratories.

A set of contiguous and partially overlapping cDNA sequences derived from urinary tract tissue, and the polypeptides encoded by the sequences, are described. The set, referred to as BL172, could be useful for detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing, treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary tract cancer. Also provided are antibodies which specifically bind to BL172-encoded proteins, and agonists or inhibitors which prevent the action of tissue-specific BL172 polypeptides.

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