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Recent Patents of Interest in Proteomics: Apr 20, 2006

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US Patent No. 7,027,933. Method for analyzing mass spectra. Inventors: Chris Paulse, Edward Gavin, Leonid Braginsky, William Rich, Eric Fung. Assignee: Ciphergen Biosystems.

This invention provides a method for analyzing mass spectra using a computer. The method involves entering a data set obtained from mass spectra from a plurality of samples into a computer. Each sample is assigned to a class within a class set, and each class is characterized by a different biological status. A classification model is formed that discriminates between the classes in a class set.


US Patent No. 7,026,167. Systems and methods for the analysis of protein phosphorylation. Inventors: Donald Hunt, Forest White, Scott Ficarro. Assignee: University of Virginia Patent Foundation.

This invention relates to a mass spectrometry-based method for the detection of protein/peptide phosphorylation. The method involves chemically modifying glutamic acid and/or aspartic acid residues found in side chains of the proteins/peptides to improve the selectivity and efficiency of identification of the phosphorylated protein/peptide.


US Patent No. 7,022,486. Peptide sequence tags and method of using same. Inventor: Douglas Campbell. Assignee: Douglas Campbell.

With this invention, peptide sequence tags are identified and used to produce a class of global antibodies that recognize all members of a particular protein family with uniform specificity, regardless of the species of origin. The tags are used to create antibodies to major proteins of photosynthesis, carbon, and nitrogen metabolism. These antibodies have a range of applications as diagnostic detection reagents for major environmental processes.


US Patent No. 7,018,801. Selection of peptides with antibody-like properties. Inventor: Thomas Kodadek. Assignee: Board of Regents, the University of Texas System.

This invention provides a sensitive screening assay for the identification of peptide binding partners to virtually any peptide or polypeptide ligand. The invention uses an expression-repression readout system.


US Patent No. 7,030,373. MALDI plate construction with grid. Inventors: Marvin Vestal, Timothy Hutchins. Assignees: Applera, MDS.

A MALDI plate construction is provided to support a sample in a manner that is conducive to mass spectrometry of the sample. The plate construction includes a sample-receiving surface, a plate holder for retaining the sample-receiving surface, an electrically conductive grid positioned adjacent to the sample-receiving surface, and an electrical contact with the plate holder.


US Patent No. 7,026,453. Method of protein purification. Inventor: Yousef Haj-Ahmad. Assignee: Norgen Biotek.

This invention provides purification methods for proteins and peptides. The methods employ silicon carbide to bind the proteins or peptides. The methods may also be used to recover and purify recombinantly expressed proteins sequestered in inclusion bodies.


US Patent No. 7,029,855. Radioactive multiplexing analytical methods for biomarker discovery. Inventor: Nathaniel Tran. Assignee: Proteomyx.

This analytical method involves labeling samples with different radioactive labeling agents, mixing and subjecting the mixture to a separation technique, and then differentially detecting and quantifying subcomponents from each sample for comparison. The technique exploits the differences in radiation energy or half-life between isotopes to make differential detection and quantification of labels possible.

The Scan

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.

Estonian Biobank Team Digs into Results Return Strategies, Experiences

Researchers in the European Journal of Human Genetics outline a procedure developed for individual return of results for the population biobank, along with participant experiences conveyed in survey data.

Rare Recessive Disease Insights Found in Individual Genomes

Researchers predict in Genome Medicine cross-population deletions and autosomal recessive disease impacts by analyzing recurrent nonallelic homologous recombination-related deletions.

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.