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Recent Patents of Interest in Proteomics: Apr 20, 2006

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US Patent No. 7,027,933. Method for analyzing mass spectra. Inventors: Chris Paulse, Edward Gavin, Leonid Braginsky, William Rich, Eric Fung. Assignee: Ciphergen Biosystems.

This invention provides a method for analyzing mass spectra using a computer. The method involves entering a data set obtained from mass spectra from a plurality of samples into a computer. Each sample is assigned to a class within a class set, and each class is characterized by a different biological status. A classification model is formed that discriminates between the classes in a class set.


US Patent No. 7,026,167. Systems and methods for the analysis of protein phosphorylation. Inventors: Donald Hunt, Forest White, Scott Ficarro. Assignee: University of Virginia Patent Foundation.

This invention relates to a mass spectrometry-based method for the detection of protein/peptide phosphorylation. The method involves chemically modifying glutamic acid and/or aspartic acid residues found in side chains of the proteins/peptides to improve the selectivity and efficiency of identification of the phosphorylated protein/peptide.


US Patent No. 7,022,486. Peptide sequence tags and method of using same. Inventor: Douglas Campbell. Assignee: Douglas Campbell.

With this invention, peptide sequence tags are identified and used to produce a class of global antibodies that recognize all members of a particular protein family with uniform specificity, regardless of the species of origin. The tags are used to create antibodies to major proteins of photosynthesis, carbon, and nitrogen metabolism. These antibodies have a range of applications as diagnostic detection reagents for major environmental processes.


US Patent No. 7,018,801. Selection of peptides with antibody-like properties. Inventor: Thomas Kodadek. Assignee: Board of Regents, the University of Texas System.

This invention provides a sensitive screening assay for the identification of peptide binding partners to virtually any peptide or polypeptide ligand. The invention uses an expression-repression readout system.


US Patent No. 7,030,373. MALDI plate construction with grid. Inventors: Marvin Vestal, Timothy Hutchins. Assignees: Applera, MDS.

A MALDI plate construction is provided to support a sample in a manner that is conducive to mass spectrometry of the sample. The plate construction includes a sample-receiving surface, a plate holder for retaining the sample-receiving surface, an electrically conductive grid positioned adjacent to the sample-receiving surface, and an electrical contact with the plate holder.


US Patent No. 7,026,453. Method of protein purification. Inventor: Yousef Haj-Ahmad. Assignee: Norgen Biotek.

This invention provides purification methods for proteins and peptides. The methods employ silicon carbide to bind the proteins or peptides. The methods may also be used to recover and purify recombinantly expressed proteins sequestered in inclusion bodies.


US Patent No. 7,029,855. Radioactive multiplexing analytical methods for biomarker discovery. Inventor: Nathaniel Tran. Assignee: Proteomyx.

This analytical method involves labeling samples with different radioactive labeling agents, mixing and subjecting the mixture to a separation technique, and then differentially detecting and quantifying subcomponents from each sample for comparison. The technique exploits the differences in radiation energy or half-life between isotopes to make differential detection and quantification of labels possible.

The Scan

Booster for At-Risk

The New York Times reports that the US Food and Drug Administration has authorized a third dose of the Pfizer-BioNTech SARS-CoV-2 vaccine for people 65 and older or at increased risk.

Preprints OK to Mention Again

Nature News reports the Australian Research Council has changed its new policy and now allows preprints to be cited in grant applications.

Hundreds of Millions More to Share

The US plans to purchase and donate 500 million additional SARS-CoV-2 vaccine doses, according to the Washington Post.

Nature Papers Examine Molecular Program Differences Influencing Neural Cells, Population History of Polynesia

In Nature this week: changes in molecular program during embryonic development leads to different neural cell types, and more.