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Recent Patents of Interest in Proteomics: May 11, 2006

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US Patent No. 7,041,459. Analyzing phosphorylated proteins. Inventors: Sharat Singh, Robert Zivin. Assignee: Monogram Biosciences.

This invention discloses methods, compositions and kits for determining one or more target polypeptides in a sample where target polypeptides have undergone phosphorylation. The method uses an immobilized metal affinity chromatography, or IMAC support specific for phosphate groups on one or more target polypeptides.


US Patent No. 7,037,894. Stabilized proteins. Inventors: Christopher Marshall, Alexander Hoffman, Joseph Errico, Paul Marshall. Assignee: Avatar Medical.

This invention provides a method for stabilization of a polypeptide or polypeptide complex. Isolated polypeptides or polypeptide chains are modified by di-tyrosine cross linking such that they retain at least one functional activity.


US Patent No. 7,041,967. Method of mass spectrometry, to enhance separation of ions with different charges. Inventor: James Hagar. Assignee: MDS.

This invention provides a method for enhancing the appearance of multiply-charged ions in the single MS survey scan by first ensuring that ions have substantially similar energies, preferably by collisional cooling, and then differentiating between the different ions by an energybarrier. The steps are preferably carried out using an ion trap, most preferably a linear ion trap.


US Patent No. 7,041,472. Method for selectively collecting N-terminal peptide fragment of protein. Inventors: Shigemi Norioka, Norikazu Ueyama, Taka-aki Okamura, Takashi Nakazawa, Minoru Yamaguchi, Eiji Ando. Assignee: Shimadzu.

This invention provides a method for selectively collecting N-terminal peptide fragments of a protein of interest, whether or not the protein of interest is modified at the N-terminus. The method involves first guanidinating the side-chain amino groups of amino acid residues, then cleaving the guanidinated protein into fragments and separating the N-terminal peptide fragment from the protein of interest from other peptide fragments by taking advantage of the difference in the reactivity or the affinity of the peptide fragments to a substrate.


US Patent No. 7,038,198. Mass spectrometer. Inventors: Shinichi Yamaguchi, Morio Ishihara, Michisato Toyoda. Assignee: Shimadzu.

This invention relates to a mass spectrometer that has a flight space wherein ions to be analyzed make orbital movements, or reciprocal movements on a substantially same orbit.


US Patent No. 7,038,197. Mass spectrometer and method of mass spectrometry. Inventors: Robert Bateman, Martin Green, Michael Jackson. Assignee: Micromass.

This invention discloses a mass spectrometer that has a z-lens upstream of an orthogonal acceleration time-of-flight mass analyzer that is repeatedly switched between a first mode, where ions are transmitted to the mass analyzer for mass analysis with a relatively high transmission, and a second mode, where ions are transmitted with a relatively low transmission.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.