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Recent Patents of Interest in Proteomics: May 11, 2006


US Patent No. 7,041,459. Analyzing phosphorylated proteins. Inventors: Sharat Singh, Robert Zivin. Assignee: Monogram Biosciences.

This invention discloses methods, compositions and kits for determining one or more target polypeptides in a sample where target polypeptides have undergone phosphorylation. The method uses an immobilized metal affinity chromatography, or IMAC support specific for phosphate groups on one or more target polypeptides.

US Patent No. 7,037,894. Stabilized proteins. Inventors: Christopher Marshall, Alexander Hoffman, Joseph Errico, Paul Marshall. Assignee: Avatar Medical.

This invention provides a method for stabilization of a polypeptide or polypeptide complex. Isolated polypeptides or polypeptide chains are modified by di-tyrosine cross linking such that they retain at least one functional activity.

US Patent No. 7,041,967. Method of mass spectrometry, to enhance separation of ions with different charges. Inventor: James Hagar. Assignee: MDS.

This invention provides a method for enhancing the appearance of multiply-charged ions in the single MS survey scan by first ensuring that ions have substantially similar energies, preferably by collisional cooling, and then differentiating between the different ions by an energybarrier. The steps are preferably carried out using an ion trap, most preferably a linear ion trap.

US Patent No. 7,041,472. Method for selectively collecting N-terminal peptide fragment of protein. Inventors: Shigemi Norioka, Norikazu Ueyama, Taka-aki Okamura, Takashi Nakazawa, Minoru Yamaguchi, Eiji Ando. Assignee: Shimadzu.

This invention provides a method for selectively collecting N-terminal peptide fragments of a protein of interest, whether or not the protein of interest is modified at the N-terminus. The method involves first guanidinating the side-chain amino groups of amino acid residues, then cleaving the guanidinated protein into fragments and separating the N-terminal peptide fragment from the protein of interest from other peptide fragments by taking advantage of the difference in the reactivity or the affinity of the peptide fragments to a substrate.

US Patent No. 7,038,198. Mass spectrometer. Inventors: Shinichi Yamaguchi, Morio Ishihara, Michisato Toyoda. Assignee: Shimadzu.

This invention relates to a mass spectrometer that has a flight space wherein ions to be analyzed make orbital movements, or reciprocal movements on a substantially same orbit.

US Patent No. 7,038,197. Mass spectrometer and method of mass spectrometry. Inventors: Robert Bateman, Martin Green, Michael Jackson. Assignee: Micromass.

This invention discloses a mass spectrometer that has a z-lens upstream of an orthogonal acceleration time-of-flight mass analyzer that is repeatedly switched between a first mode, where ions are transmitted to the mass analyzer for mass analysis with a relatively high transmission, and a second mode, where ions are transmitted with a relatively low transmission.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.