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Recent Patents of Interest in Proteomics: Jun 15, 2006

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US Patent No. 7,057,165. Probe for mass spectrometry. Inventors: Jens-Oliver Koopman, Jonathan Blackburn. Assignee: Sense Proteomic.

This invention relates to the development of a probe for the production of a protein microarray that can be interrogated by means of laser desorption/ionization mass spectrometry, particularly MALDI mass spectrometry. It also relates to methods of analyzing the protein microarray.


US Patent No. 7,052,916. Polypeptide analyses using stable isotope labeling. Inventor: Richard Johnson. Assingee: Immunex.

This invention discloses methods for incorporating a stable isotope into a protein or peptide fragment. The methods include providing isolated isotope-labeled protein or peptide fragments and analyzing the labeled fragments. Methods for quantitatively comparing peptides in two protein or peptide fragment mixtures are provided.


US Patent No. 7,052,915. Selective labeling and isolation of phosphopeptides and applications to proteome analysis. Inventors: Ruedi Aebersold, Huilin Zhou. Assignee: University of Washington.

A method for selective labeling of phosphate groups in natural and synthetic oligomers and polymers in the presence of chemically related groups such as carboxylic acid groups is disclosed. The method is specifically applicable to biological oligomers and polymers, including phosphopeptides, phosphoproteins and phospholipids. The phosphate label can be a colorimetric label, a radiolabel, a fluorescent or phosphorescent label, an affinity label, or a linker group carrying a reactive, or latent reactive group. The method can be combined with mass spectrometry to detect and identify phophopeptides and phosphoproteins.


US Patent No. RE39,099. Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use. Inventors: Andrew Krutchinsky, Alexandre Loboda, Victor Spicer, Werner Ens, Kenneth Standing. Assignee: University of Manitoba.

A method and apparatus are described for providing an ion-transmission device or interface between an ion source and a spectrometer. The ion-transmission device can include a multi-pole rod set and includes a damping gas to damp spatial and energy spreads of ions generated by a pulsed ion source. This invention has particular application to MALDI ion sources that produce a substantially non-directional jet of matrix molecules and ions, resulting in a wide range of energy spreads.



US Patent NO. 7,046,357. Apparatus for microfluidic processing and reading of biochip arrays. Inventors: Scot Weinberger, Louis Hlousek. Assignee: Ciphergen Biosystems.

This invention provides a method and device for detecting an analyte. The device is comprised of a biochip with removable microfluidic elements. The fluidic system has a removable portion. Removal of that portion renders a region directly interrogatable by a surface-based analytical tool.



US Patent No. 7,053,366. Desalting plate for MALDI mass spectrometry. Inventors: Edouard Bouvier, Bruce Compton, Dominic Gostick, Jeffery Mark Brown. Assignee: Waters Investments.

In this invention, a novel MALDI desalting sample support plate is described. Methods for making and using the sample support plate in conventional and automated MALDI-MS are also described.



US Patent No. 7,052,843. Transcription-based assay for identification of post-translational modification and its application in proteomics. Inventors: Dangsheng Li, James Yopp, Jr., Herbert Samuels. Assingee: New York University.

The invention relates to a method for detecting post-translational modifications of a target protein; a method for screening a candidate protein for E3 ligase activity; a method of screening a test compound for the ability to regulate the post-translational modification of a target protein; and a method for the large-scale detection of candidate target proteins of post-translational modification.



US Patent No. 7,045,296. Process for analyzing protein samples. Inventors: Kenneth Parker, Timothy Nadler, George Vella, Yulin Huang, Rudolf Aebersold, Marcus Smolka. Assignees: Applera; Institute for Systems Biology.

The patent describes methods that use gel electrophoresis and mass spectrometry for the rapid, quantitative analysis of proteins or protein function in protein mixtures derived from two or more samples.