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Recent Patents of Interest in Proteomics: Jul 27, 2006

US Patent 7,078,679. Inductive detection for mass spectrometry. Inventors: Michael Wesphall, Lloyd Smith. Assignee: Wisconsin Alumni Research Foundation.
The invention pertains to devices, device configurations, and methods for improved sensitivity, resolution, and efficiency in mass spectrometry. The invention provides methods and devices for analyzing and detecting electrically charged particles.

US Patent 7,075,068. Method and apparatus for electrospray augmented high field asymmetric ion mobility spectrometry. Inventors: Raanan Miller, Erikinjon Nazarov, Gary Eiceman, Evgeny Krylov. Assignee: The Charles Stark Draper Laboratory.
The invention is a system for analyzing one or more ion species in a sample. It consists of two analyzers for filtering ions through two electric fields in the flow path. The first analyzer detects ions based on the time of flight. The second detects ions based on at least one condition of the second electric field.

US Patent 7,075,065. Time of flight mass spectrometry apparatus. Inventors: Alexander Coburn, Peter Derrick, Anastassios Giannakopulos. Assignee: University of Warwick.
The invention relates to time of flight mass spectrometry apparatus. The invention provides an apparatus for the structural characterization of large molecules by TOF MS. The apparatus is made up of an ion source, bunching means, an ion mirror and a large area detector. There is also a method for the structural characterization of large molecules by TOF MS at high sensitivity and high resolution.

US Patent 7,074,936. Cleavable surfactants and methods of use thereof. Inventors: Richard Caprioli, Ned Porter, Jeremy Norris. Assignee: Vanderbilt University.
The invention relates to cleavable detergents or surfactants and methods of use thereof including isolation, solubilization, emulsification, and analysis. In particular it relates to cleavable surfactants useful for sample preparation but which can be cleaved for removal or to yield cleavage products which have additional useful properties. The cleavable detergents or surfactants of the invention improve the quality of MALDI MS analyses of proteins.

US Patent 7,074,570. Peptide fragmentation. Inventors: Ronnie Palmgren, Jean-Luc Maloisel, Maria Liminga, Thomas Keough, Robert Youngquist. Assignee: GE Healthcare Bio-Sciences.
The invention relates to a method of identifying a polypeptide in which a novel class of reagents is used to derivatize peptides before analysis using mass spectrometry. It also relates to a kit compromising such novel reagents.

US Patent 7,072,772. Method and apparatus for modeling mass spectrometer lineshapes. Inventors: Zulfikar Ahmed, Hans Bitter. Assignee: Predicant BioScience.
The invention relates to a method of analyzing mass spectra by among other things determining an initial distribution of one or more parameters of at least a first molecule; determining a theoretical modeled mass-to-charge distribution and fitting a modeled mass-to-charge molecule after it has traveled in MS to form a fitted modeled mass-to-charge distribution.

US Patent 7,070,949. Protein mixture analysis by mass spectrometry. Inventors: Detlev Suckau, Peter Hufnagel, Jochen Franzen. Assignee: Bruker Daltonik.
The invention relates to the analysis of complex protein mixtures such as entire proteomes, in particular, the rapid detection of previously unknown or unusually expressed proteins by common enzymatic digestion, subsequent chromatographic separation, and analysis of the digestion peptides by MS. Fractions of the digestion peptides separated by liquid chromatography are analyzed by MS at a time other than that of the chromatography.

US Patent 7,070,941. Methods and compositions for tagging via azido substrates. Inventor: Yingming Zhao, John Falck. Assignee: Board of Regents, The University of Texas System.
The invention provides methods and composition for azide tagging of biomolecules and allows for the detection and isolation of proteins with high yield, high specificity, and low contamination without harsh treatment of proteins.

US Patent 7,070,682. Microfluidic apparatus for performing gel protein extractions and methods for using the apparatus. Inventors: Cheng Lee, Don DeVoe. Assignee: None listed.
The invention involves rapid and efficient extraction of protein analytes directly from 2D gels using their electrophoretic mobilities. The invention involves no manual sample transfer or dilution steps in order to identify minor proteins expressed by the cells. Concentration of extracted proteins in the fluidic channels can also be achieved using electrokinetic stacking.

US Patent 7,069,152. Apparatus for identifying peptides and proteins by mass spectrometry. Inventor: John Skilling. Assignee: Micromass UK Limited.
The invention relates to the identification of a protein, polypeptide or peptide by mass spectrometry and especially tandem mass spectrometry. The apparatus models the fragmentation of a peptide or protein in a tandem mass spectrometer to facilitate comparison with an experimentally determined spectrum. A peptide or protein may be identified by comparing an experimentally determined mass spectrum with spectra detected using such a fragmentation model from a library of known peptides or proteins.

US Patent, 7,069,151. Mapping of differential display of proteins. Inventors: David Lubman, Bathsheba Chong, Stephen Parus. Assignee: Regents of the University of Michigan.
The invention relates to protein separation systems and methods to resolve and characterize large numbers of cellular proteins. The invention provides a new mass mapping system and methods for differential display of proteins and methods for displaying differential protein expression between two samples.

US Patent 7,061,605. Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions. Inventors: Anthony Lemmo, Javier Gonzalez-Zugasti, Michael Cima, Douglas Levinson, Alasdair Johnson, Orn Almarsson, Christopher McNulty. Assignee: Transform Pharmaceuticals.

The invention relates to systems and methods allowing high-throughput preparation, processing, and study of arrays of samples, each made up of at least one compound. Some embodiments of the invention allow a large number of experiments to be done in parallel on samples comprised of one or more compounds on the milligram or microgram quantities of compounds.

The Scan

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.

Machine Learning Improves Diagnostic Accuracy of Breast Cancer MRI, Study Shows

Combining machine learning with radiologists' interpretations further increased the diagnostic accuracy of MRIs for breast cancer, a Science Translational Medicine paper finds.

Genome Damage in Neurons Triggers Alzheimer's-Linked Inflammation

Neurons harboring increased DNA double-strand breaks activate microglia to lead to neuroinflammation like that seen in Alzheimer's disease, a new Science Advances study finds.

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.